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首页> 外文期刊>FEBS Open Bio >Covalent bonding of heme to protein prevents heme capture by nontypeable Haemophilus influenzae
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Covalent bonding of heme to protein prevents heme capture by nontypeable Haemophilus influenzae

机译：血红素与蛋白质的共价结合可防止不可分型流感嗜血杆菌捕获血红素

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Nontypeable Haemophilus influenzae (NTHi) are Gram‐negative pathogens that contribute to a variety of diseases, including acute otitis media and chronic obstructive pulmonary disease. As NTHi have an absolute requirement for heme during aerobic growth, these bacteria have to scavenge heme from their human hosts. These heme sources can range from free heme to heme bound to proteins, such as hemoglobin. To test the impact of heme structural factors on heme acquisition by NTHi, we prepared a series of heme sources that systematically vary in heme exposure and covalent binding of heme to peptide/protein and tested the ability of NTHi to use these sources to support growth. Results from this study suggest that NTHi can utilize protein‐associated heme only if it is noncovalently attached to the protein.
机译：不可分型流感嗜血杆菌（NTHi）是革兰氏阴性病原体，可导致多种疾病，包括急性中耳炎和慢性阻塞性肺疾病。由于NTHi在有氧生长过程中绝对需要血红素，因此这些细菌必须清除人类宿主中的血红素。这些血红素来源的范围从游离血红素到结合到蛋白质（例如血红蛋白）的血红素。为了测试血红素结构因子对NTHi采集血红素的影响，我们制备了一系列血红素来源，这些血红素来源在血红素暴露和血红素与肽/蛋白质的共价结合方面发生了系统性变化，并测试了NTHi使用这些来源支持生长的能力。这项研究的结果表明，NTHi仅在与蛋白质非共价结合时才能利用与蛋白质相关的血红素。

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