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首页> 外文期刊>Radiology and Oncology >Cysteine cathepsins and stefins in head and neck cancer: an update of clinical studies
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Cysteine cathepsins and stefins in head and neck cancer: an update of clinical studies

机译：半胱氨酸组织蛋白酶和stefins在头颈癌：临床研究的更新

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Background. Cancer of the head and neck represents a diverse group of malignant diseases; so far, no factor in a wide spectrum of biochemical and histological candidate-markers has yet been identified to predict reliably the natural course of the disease or its response to the therapy to be used in routine clinical practice. Among the factors that promote tumor growth and invasion, several protease systems, implemented in proteolytic degradation of extracellular matrix components, were studied, including papain-like lysosomal cysteine proteases (e.g. cathepsins B and L) and their physiological inhibitors cystatins (e.g. stefins A and B, cystatin C). The aim of the present report is to review the published studies on clinical applicability of cysteine cathepsins and their endogenous inhibitors stefins in squamous cell carcinoma of the head and neck and to present recent research results from this area conducted jointly by the Institute of Oncology Ljubljana and ENT Department of the University Medical Center Ljubljana, Slovenia.Conclusions. According to our experience, immunohistochemical staining of cysteine cathepsins and stefins seems to be of limited value for predicting either treatment response or patients' survival. However, the results of studies on stefin A in tumor tissue cytosols should be considered hypothesis-generating and deserves further evaluation in the frame of prospective controlled multicentric clinical study.
机译：背景。头颈癌代表各种各样的恶性疾病。迄今为止，还没有发现广泛的生化和组织学候选标记中的因素能够可靠地预测疾病的自然病程或其对常规临床实践中使用的疗法的反应。在促进肿瘤生长和侵袭的因素中，研究了在细胞外基质成分的蛋白水解降解中实施的几种蛋白酶系统，包括木瓜蛋白酶样溶酶体半胱氨酸蛋白酶（例如组织蛋白酶B和L）及其生理抑制剂胱抑素（例如Stefins A和B，胱抑素C）。本报告的目的是回顾已发表的关于半胱氨酸组织蛋白酶及其内源性抑制剂stefins在头颈部鳞状细胞癌中的临床应用研究，并介绍卢布尔雅那肿瘤研究所与该领域联合进行的该领域的最新研究结果。斯洛文尼亚卢布尔雅那大学医学中心耳鼻喉科。结论。根据我们的经验，半胱氨酸组织蛋白酶和stefins的免疫组织化学染色似乎在预测治疗反应或患者生存方面价值有限。然而，有关肿瘤组织细胞溶胶中甜菊素A的研究结果应被认为是假说的产生，并应在前瞻性对照多中心临床研究的框架内进行进一步评估。

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