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首页> 外文期刊>Radiology and Oncology >Accuracy of 18F-flurodeoxyglucosepositron emission tomography/computed tomography in the staging of newly diagnosed nasopharyngeal carcinoma: a systematic review and meta-analysis
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Accuracy of 18F-flurodeoxyglucosepositron emission tomography/computed tomography in the staging of newly diagnosed nasopharyngeal carcinoma: a systematic review and meta-analysis

机译：18 F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描在新诊断的鼻咽癌分期中的准确性：系统评价和荟萃分析

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Background. The specific role of 18F-flurodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in staging of nasopharyngeal carcinoma (NPC) remains to be validated. A systematic review and meta-analysis were performed to assess the accuracy of staging FDG-PET/CT for newly diagnosed NPC. Methods. We searched various biomedical databases and conference proceedings for relevant studies. We determined the pooled sensitivities and specificities, diagnostic odds ratios (DOR) and constructed summary receiver operating characteristic (SROC) curves using the hierarchical regression model. Results. 15 relevant studies including 851 patients were identified. Five addressed primary tumor (T), nine addressed regional lymph nodes (N) and seven addressed distant metastasis (M). The combined sensitivity estimate for FDG-PET/CT in T classification was 0.77 (95% confidence interval [CI] 0.59-0.95). For N classification, combined sensitivity was 0.84 (95% CI 0.76-0.91), specificity was 0.90 (95% CI 0.83-0.97), DOR was 82.4 (23.2-292.6) and Q*-index was 0.90. For M classification, the combined sensitivity estimate was 0.87 (95% CI 0.74-1.00), specificity was 0.98 (95% CI 0.96-1.00), DOR was 120.9 (43.0-340.0) and Q*-index was 0.89. Conclusion. FDG-PET/CT showed good accuracy in N and M but not T classification for newly diagnosed NPC. FDG-PET/CT, together with Magnetic resonance imaging (MRI) of the nasopharynx, should be part of the routine staging investigations
机译：背景。 18F-氟脱氧葡萄糖-正电子发射断层扫描/计算机断层扫描（FDG-PET / CT）在鼻咽癌（NPC）分期中的特殊作用仍有待验证。进行了系统的审查和荟萃分析，以评估FDG-PET / CT对新诊断的鼻咽癌的分期准确性。方法。我们搜索了各种生物医学数据库和会议记录以进行相关研究。我们确定了合并的敏感性和特异性，诊断比值比（DOR），并使用分层回归模型构建了摘要接收者操作特征（SROC）曲线。结果。确定了15项相关研究，包括851例患者。 5个针对原发性肿瘤（T），9个针对区域淋巴结（N）和7个针对远处转移（M）。 T分类中FDG-PET / CT的综合敏感性估计为0.77（95％置信区间[CI] 0.59-0.95）。对于N分类，组合灵敏度为0.84（95％CI 0.76-0.91），特异性为0.90（95％CI 0.83-0.97），DOR为82.4（23.2-292.6）和Q *指数为0.90。对于M分类，组合的敏感性估计值为0.87（95％CI 0.74-1.00），特异性为0.98（95％CI 0.96-1.00），DOR为120.9（43.0-340.0），Q *指数为0.89。结论。 FDG-PET / CT对新诊断的NPC在N和M方面显示出良好的准确性，但在T分类中却没有。 FDG-PET / CT与鼻咽磁共振成像（MRI）一起应作为常规分期检查的一部分

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