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首页> 外文期刊>Renal failure. >Associations of Plasma Pentraxin 3 and Monocyte Chemoattractant Protein-1 Concentrations with Cardiovascular Disease in Patients with Chronic Kidney Disease
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Associations of Plasma Pentraxin 3 and Monocyte Chemoattractant Protein-1 Concentrations with Cardiovascular Disease in Patients with Chronic Kidney Disease

机译：慢性肾脏病患者血浆Pentraxin 3和单核细胞趋化蛋白1浓度与心血管疾病的关系

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We examined the associations of circulating levels of pentraxin 3 (PTX3), monocyte chemoattractant protein-1 (MCP-1), and some other inflammatory mediators with cardiorenal syndrome. In advanced chronic kidney disease (CKD) patients (estimated glomerular filtration rate 30 mL/min/1.73 m2), the values of area under the curve of PTX3, tumor necrosis factor α, and high-sensitivity C-reactive protein for the detection of the association of cardiovascular disease (CVD) were 0.664, 0.507, and 0.318, respectively. In contrast, serum levels of MCP-1 were significantly higher in CKD patients than in control subjects independently of association with CVD. Both pentraxin 3 (PTX3) and monocyte chemoattractant protein-1 (MCP-1) are mediators of inflammation. They also appear to play critical roles in vascular endothelial dysfunction but their associations with cardiorenal syndrome remain largely unknown. The objective of this study was to examine their associations with cardiorenal syndrome. Circulating levels of PTX3, MCP-1, and some other biomarkers were evaluated in 134 patients with chronic kidney disease (CKD) and/or cardiovascular disease (CVD) and 55 age- and gender-matched subjects without CKD or CVD. Levels of PTX3, high-sensitivity C-reactive protein (hsCRP), and tumor necrosis factor α (TNFα) were significantly higher in CKD patients with CVD than in those without CVD. In advanced CKD patients (estimated glomerular filtration rate 30 mL/min/1.73 m2), the values of area under the curve of PTX3, TNFα, and hsCRP for the detection of the association of CVD were 0.664, 0.507, and 0.318, respectively. In contrast, serum levels of MCP-1 were significantly higher in CKD patients than in control subjects independently of association with CVD. PTX3, hsCRP, and TNFα, but not MCP-1 could predict the presence of CVD as a complication associated with CKD. Additionally, PTX3 might be a more sensitive marker for the association of CVD than hsCRP and TNFα in patients with advanced CKD.
机译：我们检查了五环素3（PTX3），单核细胞趋化蛋白-1（MCP-1）和其他一些与心肾综合征的炎症介质的循环水平之间的关联。在晚期慢性肾脏病（CKD）患者中（估计肾小球滤过率<30 mL / min / 1.73 m 2 ），PTX3曲线下面积，肿瘤坏死因子α和高用于检测心血管疾病（CVD）关联的敏感性C反应蛋白分别为0.664、0.507和0.318。相反，独立于CVD的情况，CKD患者的MCP-1血清水平明显高于对照组。 pentraxin 3（PTX3）和单核细胞趋化蛋白1（MCP-1）都是炎症的介质。它们在血管内皮功能障碍中似乎也起着关键作用，但是它们与心肾综合征的联系仍是未知的。这项研究的目的是检查他们与心肾综合征的关系。在134名患有慢性肾脏病（CKD）和/或心血管疾病（CVD）的患者以及55名年龄和性别相匹配的无CKD或CVD的受试者中评估了PTX3，MCP-1和其他一些生物标志物的循环水平。患有CVD的CKD患者的PTX3，高敏C反应蛋白（hsCRP）和肿瘤坏死因子α（TNFα）的水平显着高于没有CVD的患者。在晚期CKD患者中（估计肾小球滤过率<30 mL / min / 1.73 m 2 ），用于检测CVD关联的PTX3，TNFα和hsCRP曲线下的面积值为分别为0.664、0.507和0.318。相反，独立于CVD的情况，CKD患者的MCP-1血清水平明显高于对照组。 PTX3，hsCRP和TNFα而非MCP-1可以预测CVD的存在与CKD相关。另外，在晚期CKD患者中，PTX3可能是比hsCRP和TNFα更敏感的CVD关联标志。

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