Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages

Parisa Ghasemiyeh; Soliman Mohammadi-Samani

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Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages

机译：固体脂质纳米颗粒和纳米结构脂质载体作为新型药物传递系统：应用，优点和缺点

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During the recent years, more attentions have been focused on lipid base drug delivery system to overcome some limitations of conventional formulations. Among these delivery systems solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) are promising delivery systems due to the ease of manufacturing processes, scale up capability, biocompatibility, and also biodegradability of formulation constituents and many other advantages which could be related to specific route of administration or nature of the materials are to be loaded to these delivery systems. The aim of this article is to review the advantages and limitations of these delivery systems based on the route of administration and to emphasis the effectiveness of such formulations.

机译：近年来，为了克服常规制剂的某些限制，更多的注意力集中在脂质基础药物递送系统上。在这些输送系统中，固体脂质纳米颗粒（SLN）和纳米结构脂质载体（NLC）具有广阔的发展前景，因为它们易于制造，易于规模化生产，具有生物相容性，而且配方成分具有生物降解性，并且还具有许多其他优点，特定的给药途径或材料性质应加载到这些输送系统中。本文的目的是根据给药途径来审查这些给药系统的优点和局限性，并强调此类制剂的有效性。

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《Research in Pharmaceutical Sciences》 |2018年第4期|共16页
作者
Parisa Ghasemiyeh; Soliman Mohammadi-Samani;
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中图分类药学;
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Solid lipid nanoparticles and nanostructured lipid carriers as novel drug delivery systems: applications, advantages and disadvantages

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