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首页> 外文期刊>Research in Obstetrics and Gynecology >Birth Weight in Relation to Fetal and Maternal Leptin and Insulin: A Systematic Review and Meta-analysis
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Birth Weight in Relation to Fetal and Maternal Leptin and Insulin: A Systematic Review and Meta-analysis

机译：与胎儿和母体瘦素及胰岛素相关的出生体重：系统评价和荟萃分析

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leptin and insulin have been implicated in fetal growth regulation and investigated repeatedly with controversial outcomes. A systematic review and meta-analysis were conducted according to MOOSE guidelines to establish if consistency exists in the reported literature so that the role of maternal and fetal insulin and leptin in fetal growth could be assessed. A robust recognised systematic methodology was used in the literature search and data extraction and analysis to avoid bias. SPSS version 16 and RevMan 4.2 were used for statistical analysis and the results presented as a Weighted Mean Difference (WMD) and 95% CI. Nineteen studies were included. Large for gestational age babies (LGA) had significantly higher cord serum insulin and leptin levels than was adequate for gestational age (AGA) ones[3.16 μIU/ml (0.85, 5.48) and -4.33 ng/ml (-5.30, -3.36) respectively]. Small for gestational age babies (SGA) had similar insulin levels but significantly lower cord leptin[21 μIU/ml (-5.69, 1.27)] than AGA babies[-3.07ng/ml (-4.57, -1.58)]. Maternal serum levels of leptin were similar between mothers of LGA, SGA and AGA babies. Conclusion: although both fetal insulin and leptin reflect the degree of fetal adiposity, leptin may have growth promoting properties.
机译：瘦素和胰岛素与胎儿生长调节有关，并以有争议的结果进行了反复研究。根据MOOSE指南进行了系统的综述和荟萃分析，以确定所报道文献中是否存在一致性，以便可以评估母体和胎儿胰岛素以及瘦素在胎儿生长中的作用。在文献搜索以及数据提取和分析中使用了一种可靠的公认系统方法，以避免偏差。使用SPSS版本16和RevMan 4.2进行统计分析，结果以加权平均差（WMD）和95％CI表示。包括19个研究。大胎龄婴儿（LGA）的脐带血胰岛素和瘦素水平明显高于胎龄婴儿（AGA）的[3.16μIU/ ml（0.85，5.48）和-4.33 ng / ml（-5.30，-3.36）分别]。小型胎龄婴儿（SGA）的胰岛素水平相似，但脐带瘦素[21μIU/ ml（-5.69，1.27）]明显低于AGA婴儿[-3.07ng / ml（-4.57，-1.58）]。 LGA，SGA和AGA婴儿的母亲的血清瘦素水平相似。结论：尽管胎儿胰岛素和瘦素均可反映胎儿的肥胖程度，但瘦素可能具有促进生长的特性。

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