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首页> 外文期刊>Research in Pharmaceutical Sciences >Evaluation of cardioprotective effect of aqueous extract of Allium cepa Linn. bulb on isoprenaline-induced myocardial injury in Wistar albino rats
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Evaluation of cardioprotective effect of aqueous extract of Allium cepa Linn. bulb on isoprenaline-induced myocardial injury in Wistar albino rats

机译：葱葱水提取物的心脏保护作用评价。灯泡对异丙肾上腺素致Wistar白化病大鼠心肌的损伤

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To investigate the cardioprotective potential of the aqueous extract of Allium cepa Linn. bulb in isoprenaline-induced myocardial injury in Wistar albino rats. In vitro total phenolic, total flavonoid content and 2, 2’-diphenyl-1-picrylhydrazyl hydrate radical scavenging activity was measured. Isoprenaline-induced myocardial injury model was used to evaluate in vivo effect of aqueous extract of A. cepa in Wistar albino rats. Seventy two rats were randomly divided in 6 groups. Rats were treated with A. cepa 400 mg/kg and 800 mg/kg doses for 30 days and myocardial injury was produced by subcutaneous injection of isoprenaline (ISO) 85 mg/kg on day 28 and 29. Carvedilol 1 mg/kg for 30 days served as active control. Electrocardiogram parameters, cardiac injury markers, oxidative stress markers and histopathological changes were evaluated in each group and compared using appropriate statistical tests. In vitro evaluation of aqueous extract of A. cepa showed significant antioxidant property. ISO produced significant myocardial injury as compared to normal control group ( P 0.05). The aqueous extract of A. cepa 400 mg/kg was found to be cardioprotective against myocardial injury while A. cepa 800 mg/kg did not show significant cardioprotective activity. So, we presume that A. cepa might be effective within certain dose range only.
机译：为了调查葱属的水提取物的心脏保护潜力。在异戊二烯诱导的Wistar白化病大鼠心肌损伤中的电灯泡。测定了体外总酚，总类黄酮含量和2，2'-二苯基-1-吡啶并肼基水合物自由基清除活性。异丙肾上腺素诱导的心肌损伤模型用于评估Wistar白化病大鼠的A. cepa水提取物的体内作用。将72只大鼠随机分为6组。大鼠分别接受400 mg / kg和800 mg / kg剂量的洋葱曲霉（A. cepa）治疗30天，并在第28天和第29天皮下注射异丙肾上腺素（ISO）85 mg / kg产生心肌损伤。卡维地洛1 mg / kg持续30天天作为主动控制。在每组中评估心电图参数，心脏损伤标志物，氧化应激标志物和组织病理学变化，并使用适当的统计检验进行比较。洋葱曲霉的水提取物的体外评估显示出显着的抗氧化性能。与正常对照组相比，ISO产生了明显的心肌损伤（P 0.05）。发现洋葱曲霉400mg / kg的水提取物对心肌损伤具有心脏保护作用，而洋葱曲霉800mg / kg没有显示出明显的心脏保护活性。因此，我们假定洋葱曲霉仅在一定剂量范围内可能有效。

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