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首页> 外文期刊>Reproductive Biology and Endocrinology >Fatty acid composition of the follicular fluid of normal weight, overweight and obese women undergoing assisted reproductive treatment: a descriptive cross-sectional study
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Fatty acid composition of the follicular fluid of normal weight, overweight and obese women undergoing assisted reproductive treatment: a descriptive cross-sectional study

机译：正常体重，超重和肥胖妇女接受辅助生殖治疗的卵泡液中脂肪酸成分的描述性横断面研究

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Background It has been well documented that the maturing oocyte is very vulnerable to changes in its micro-environment, the follicular fluid (FF). Recent research has focused on different components within this FF, like hormones, growth factors and metabolites, and how their concentrations are altered by diet and the metabolic health of the mother. It has been proposed that fatty acids (FAs) are potential factors that influence oocyte maturation and subsequent embryo development. However, a thorough study of the specific FF FA composition per lipid fraction and how this may be affected by BMI is currently lacking. Therefore, we investigated the BMI-related concentration of FAs in the phospholipid (PL), cholesteryl-ester (CHE), triglyceride (TG) and non-esterified (NE) lipid fraction in the FF of women undergoing assisted reproductive treatment (ART). Methods In this descriptive cross-sectional study, the FF of normal weight (18.5?≤?BMI? Results Total FA concentrations in the PL and CHE fraction did not differ between BMI groups. Total TG concentrations tended to differ and total NEFA concentrations differed significantly between BMI groups. Interestingly, 42% and 34% of the total FAs was esterified in the PL and CHE fraction, respectively, while only 10% were present in both the TG and NEFA fraction. Only few individual FA concentrations differed in the PL, CHE and TG fraction between BMI groups, whereas abundant BMI-related differences were found in the NEFA fraction. Conclusions Our data show that differences in BMI are associated with alterations in the FA composition of the FF, an effect most pronounced in the NEFA fraction. These BMI-related variations could possibly affect granulosa cell viability, oocyte developmental competence and subsequent embryo quality possibly explaining differences in oocyte quality in obese patients described by others.
机译：背景技术已经有充分的文献证明，成熟的卵母细胞非常容易受到其微环境卵泡液（FF）的变化的影响。最近的研究集中在FF中的不同成分，例如激素，生长因子和代谢产物，以及它们的浓度如何通过饮食和母亲的代谢健康而改变。已经提出，脂肪酸（FAs）是影响卵母细胞成熟和随后的胚胎发育的潜在因素。但是，目前尚缺乏对每个脂质组分的特定FF FA组成以及BMI如何对其影响的透彻研究。因此，我们调查了接受辅助生殖治疗（ART）的女性FF中磷脂（PL），胆固醇酯（CHE），甘油三酸酯（TG）和非酯化（NE）脂质部分中FA的BMI相关浓度。方法在该描述性横断面研究中，正常体重的FF（18.5≤BMI）结果各BMI组之间PL和CHE分数中的FA总浓度无差异，总TG浓度趋于差异，而NEFA总浓度差异显着有趣的是，在PL和CHE馏分中，分别有42％和34％的FA被酯化，而在TG和NEFA馏分中都只有10％被酯化。 BMI组之间的​​CHE和TG分数不同，而NEFA分数中存在大量与BMI相关的差异结论结论我们的数据表明BMI差异与FF的FA组成改变有关，NEFA分数最明显。这些与BMI相关的变异可能会影响颗粒细胞活力，卵母细胞发育能力和随后的胚胎质量，这可能解释了肥胖患者卵母细胞质量的差异被其他人描述。

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