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首页> 外文期刊>Research Journal of Medical Sciences >Vertical Transmission of HIV: A Review on Epidemiology, Pathogenesis, Prevention, Treatment Strategies and Toxicity of Drugs
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Vertical Transmission of HIV: A Review on Epidemiology, Pathogenesis, Prevention, Treatment Strategies and Toxicity of Drugs

机译：HIV的垂直传播：药物的流行病学，发病机制，预防，治疗策略和毒性研究述评

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Acquired Immunodeficiency Syndrome (AIDS) is the most fatal disorder caused by Human Immunodeficiency Virus (HIV) infection. There has not been any successful chemotherapy developed so far and the infection continues to plague many countries across the globe through last two and a half decades. Heterosexual contact is the predominant mode of transmission among women of childbearing age and consequently the infants are afflicted. Vertical transmission is one of the major etiological factors for HIV/AIDS in children. The infection is symptomatic in the beginning and subsequently progress rapidly. Co-morbidity and rate of mortality is high. Notwithstanding, tremendous progression of technical and scientific capabilities, the world is still not able to control the epidemic of vertical transmission. As of December 2006, about 2.3 million children are living with HIV and the death figures reach 0.38 million. In view of the deteriorating situation of the mortality and co-morbidity of HIV infection among children and lack of literature on vertical transmission, an attempt was made to review some of the crucial publications. Our study correlated some of the important aspects on epidemiology, pathogenesis, co-morbidity, mortality, prevention, treatment strategies (both HIV infection and co-morbidity) and toxicity of drugs. It is concluded that further deterioration in the present status of HIV infection could be avoided by giving priority to developing effective strategies and preventive measures to target the properties of transmitted viruses.
机译：获得性免疫缺陷综合症（AIDS）是由人类免疫缺陷病毒（HIV）感染引起的最致命的疾病。迄今为止，尚未成功开发出任何成功的化学疗法，并且在过去的两年半的时间里，感染继续困扰着全球许多国家。异性接触是育龄妇女中的主要传播方式，因此婴儿受了折磨。垂直传播是儿童艾滋病毒/艾滋病的主要病因之一。感染在开始时是有症状的，随后迅速发展。合并症和死亡率很高。尽管技术能力和科学能力取得了巨大进步，但世界仍无法控制垂直传播的流行。截至2006年12月，约有230万儿童感染艾滋病毒，死亡人数达38万。鉴于儿童中艾滋病毒感染的死亡率和合并症的恶化情况以及缺乏垂直传播的文献，人们试图审查一些重要的出版物。我们的研究将流行病学，发病机制，合并症，死亡率，预防，治疗策略（HIV感染和合并症）以及药物毒性等重要方面联系起来。结论是，通过优先制定针对传播病毒特性的有效策略和预防措施，可以避免艾滋病毒感染现状的进一步恶化。

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