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首页> 外文期刊>Research Journal of Medical Sciences >Anti-Inflammatory Activity of Ethanolic Leaf Extract from Vernonia amygdalina on the Immune System of Swiss Albino Rats Dosed with Clostridium sporogenes (NCIB 532)
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Anti-Inflammatory Activity of Ethanolic Leaf Extract from Vernonia amygdalina on the Immune System of Swiss Albino Rats Dosed with Clostridium sporogenes (NCIB 532)

机译：扁桃Vernonia杏仁叶的乙醇提取物对产孢梭状芽孢杆菌瑞士白化病大鼠免疫系统的抗炎活性（NCIB 532）

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The result presented in this research revealed the effect of oral administration of ethanolic leaf extract from Vernonia amygdalina as an anti-inflammatory as well as immunoregulatory agent in Swiss albino rats dosed with standard inoculums of Clostridium sporogenes (NCIB 532). Forty eight Swiss albino rats were used and divided into six groups. The first group was given normal saline, the second group was given 8 mL of the standard inoculum of the Clostridium sporogenes only and the third group was given the standard inoculum at the same time treated with the ethanolic leaf extract from Vernonia amygdalina. The other groups were given the booster inoculum of organism and booster shots after 3 and 5 days, respectively. Heamatological tests were carried out to determine the effect of the extract on the total white blood cell counts, packed cell volume, Neutrophil, Eosinophil and lymphocyte of the rats before, during and after infection. The result shows an increase in total WBC in the infected rat but the value reduces after treatment with Vernonia extract. Conversley, the PCV reduces in the in the untreated infected rat but the value became elevated after oral administration of the extract. Neutrophil values reduces during infection but the values became normal after treatment. Also urinalysis was carried out, both macroscopy and microscopy before, during and immediately after the infection in order to evaluate the immunomodulatory effects of the extract on the immune system of the infected rats. The rats were also weighed before, during and after infection, in which there was reduction in their weights during active infection in those that were dosed with the organism due to infection while those that were dosed with the Clostridium sporogenes and treated with leaf extract from Vernonia amygdalina and those given the extract only, showed an increase in their body weights respectively. This result showed that the ethanolic leaf extract from Vernonia amygdalina has immunomodulatory properties and it is able to inhibit proliferation of Clostridium sporogenes.
机译：这项研究提出的结果揭示了口服杏仁核Vernonia乙醇叶提取物作为消炎药和免疫调节剂在瑞士白化病大鼠中的作用，该大鼠已接种了标准的产孢梭状芽孢杆菌（NCIB 532）。使用四十八只瑞士白化病大鼠，分为六组。第一组给予生理盐水，第二组仅给予8 mL产孢梭状芽孢杆菌标准接种物，第三组同时给予标准接种物，用杏仁核Vernonia的乙醇叶提取物处理。其他组分别在第3天和第5天接受了生物体的加强接种和加强注射。进行血液学测试以确定提取物对感染前，感染中和感染后白细胞总数，堆积细胞体积，中性粒细胞，嗜酸性粒细胞和淋巴细胞的影响。结果表明，感染的大鼠中总白细胞增加，但是用Vernonia提取物处理后，白细胞中的WBC减少。孔弗斯利（Conversley），未经处理的感染大鼠的PCV降低，但在口服给予提取物后其值升高。感染期间中性粒细胞值降低，但治疗后该值恢复正常。还在感染之前，期间和之后立即进行了尿液分析，包括肉眼检查和显微镜检查，以评估提取物对被感染大鼠免疫系统的免疫调节作用。还在感染之前，期间和之后对大鼠进行称重，在这种情况下，在主动感染过程中，由于感染而给予生物体的大鼠体重减轻了，而对芽孢梭状芽孢杆菌给予了剂量，并用了Vernonia的叶提取物进行了处理。杏仁核和仅给予提取物的杏仁核分别显示出体重增加。该结果表明，来自杏仁核Vernonia的乙醇叶提取物具有免疫调节特性，并且能够抑制芽孢梭菌的增殖。

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