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首页> 外文期刊>Research Opinions in Animal & Veterinary Sciences >Evaluation of the wound healing activity of methanolic extract of Tragopogon porrifolius in rat
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Evaluation of the wound healing activity of methanolic extract of Tragopogon porrifolius in rat

机译：刺五加甲醇提取物对大鼠伤口愈合活性的评价

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This study was undertaken to evaluate the wound healing properties of Tragopogon porrifolius (TP) on cutaneous wounds in rat. A full-thickness cutaneous defect (2×2cm) was induced on the back of 60 Sprague-Dawley rats. The animals were randomly divided into four equal groups, treated with 1ml basal cream (placebo group), 1ml tetracycline (3%), 1ml TP 10% and untreated (control). Five animals of each group were euthanized at each of 7, 14 and 21 days post-injury (DPI) and wounds were evaluated through histopathological analyses. Treated animals with TP showed a significant reduction in the wound surface area at 14 and 21 DPI compared to other groups. In addition, treatment with TP reduced the number of lymphocytes and enhanced the number of fibroblasts at the earlier stages of wound healing and increased number of fibrocytes at the later stages of wound healing. TP significantly improved alignment of the healing tissue, re-epithelilization and epithelial formation, enhanced maturity of the collagen fibres and fibroblasts and large capillary-sized blood vessels. The present study demonstrated that the methanolic extract of T. porrifolius promoted wound healing activity in animal as a preclinical study. These results showed that application of TP extract on wounds induces significant wound contraction and accelerated healing and it may be suggested for treating various types of wounds in animal and human beings.
机译：进行这项研究以评估刺五加（TP）在大鼠皮肤伤口上的伤口愈合特性。在60只Sprague-Dawley大鼠的背部诱发了全层皮肤缺损（2×2cm）。将动物随机分为四个相等的组，分别用1ml基础乳霜（安慰剂组），1ml四环素（3％），1ml TP 10％和未处理（对照）治疗。在损伤后第7、14和21天分别对每组五只动物实施安乐死，并通过组织病理学分析评估伤口。与其他组相比，用TP处理的动物在14和21 DPI时伤口表面积显着减少。此外，在伤口愈合的早期，TP处理减少了淋巴细胞的数量，增加了成纤维细胞的数量，而在伤口愈合的后期则增加了纤维细胞的数量。 TP显着改善了愈合组织的排列，重新上皮形成和上皮形成，增强了胶原纤维和成纤维细胞的成熟度以及较大的毛细血管。本研究表明，作为临床前研究，紫锥花的甲醇提取物可促进动物伤口愈合活性。这些结果表明，TP提取物在伤口上的应用引起明显的伤口收缩和加速的愈合，并且可能被建议用于治疗动物和人类中的各种伤口。

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