首页> 外文期刊>Revista Argentina de Dermatología >Melanoma acral lentiginoso (MAL): experiencia del Instituto Nacional de Cancerología de Colombia. 2003-2006
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Melanoma acral lentiginoso (MAL): experiencia del Instituto Nacional de Cancerología de Colombia. 2003-2006

机译:急性肺部黑色素瘤(MAL):哥伦比亚国家癌症研究所的经验。 2003-2006

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Introduction: Acral Lentiginous Melanoma (ALM) is a variation of malignant melanoma which frequently occurs in Latin America; in developed countriesit accounts for 2-8% of all melanoma types; in Colombia, 15% of all melanoma cases are classified as ALM.Histopathological characteristics of acral lentiginous melanoma patients treated at the National Cancer Institute of Colombia (NCI) during the years 2003-2006. This is the first descriptive report carried out on ALM in our country, and is among the few conducted in the world.Methods: an observational, retrospective study compiled the clinical and epidemiological characteristics of all acral lentiginous melanoma patientstreated at the National Cancer Institute of Colombia during the years 2003-2006.Results: ALM patients accounted for 25% of all melanoma cases treated at the National Cancer Institute. A total of 93 patients were treated over thecourse of the study, 78 of whom underwent surgery. Advanced cases (Stages III and IV) made up 33% (n=31) of the total; among tumor antecedents,trauma at lesion site came to 11.8% (n=11).Non-solar exposure as a risk factor was reported in 64.5% (n=60) of patients; three patients (3.4%) had immediate family history of melanoma. Lowerlimb involvement prevailed, 88.1% (n=82) of which toes and soles of the feet were the most frequent sites, 94% (n=77). Three quarters (75%) of the 59patients who underwent surgery received sentinel lymph node surgery. Other treatments included: adjuvant therapy with interpheron-alpha in 14 (18%)patients, chemotherapy in 8 patients (10.2%), radiotherapy in 18 patients (23%), surgery plus chemotherapy in 8 patients (10.2%), surgery plusradiotherapy in 18 patients (23%), and surgery plus chemotherapy plus radiotherapy in 3 patients (3.8%).Conclusion: this study describes the epidemiological characteristics of ALM in Colombia and provides a reference for the local study of this frequentmelanoma variation in our population.
机译:简介:急性唇黑色素瘤(ALM)是恶性黑色素瘤的一种变体,在拉丁美洲经常发生。在发达国家,它占所有黑色素瘤类型的2-8%;在哥伦比亚,所有黑色素瘤病例中有15%被归类为ALM。2003-2006年间,在哥伦比亚国家癌症研究所(NCI)接受治疗的手性慢性黑色素瘤患者的病理组织学特征。方法:一项观察性,回顾性研究汇总了哥伦比亚国立癌症研究所治疗​​的所有手足部慢性黑色素瘤患者的临床和流行病学特征,这是在美国进行的关于ALM的首次描述性报告。结果:2003年至2006年期间,ALM患者占美国国家癌症研究所治疗​​的所有黑色素瘤病例的25%。在研究过程中共治疗了93名患者,其中78名接受了手术。晚期病例(第三和第四阶段)占总数的33%(n = 31);在肿瘤前体中,病变部位的创伤达到11.8%(n = 11)。非太阳暴露是危险因素,在64.5%(n = 60)的患者中有报道。三名患者(3.4%)有黑色素瘤家族史。下肢受累占优势,占88.1%(n = 82),其中脚趾和脚底是最常见的部位,占94%(n = 77)。在接受手术的59位患者中,四分之三(75%)接受了前哨淋巴结手术。其他治疗方法包括:14例(18%)患者接受α-干扰素辅助治疗,8例患者(10.2%)接受化疗,18例患者(23%)接受放射治疗,8例患者接受手术加化疗(10.2%),结论:本研究描述了哥伦比亚ALM的流行病学特征,为18例患者(23%)和外科手术加化学疗法加放射疗法的3例患者(3.8%)提供了参考,为本地研究这种人群中常见的黑色素瘤变异提供了参考。

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