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首页> 外文期刊>Radiation oncology >Do patients with very few brain metastases from breast cancer benefit from whole-brain radiotherapy in addition to radiosurgery?
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Do patients with very few brain metastases from breast cancer benefit from whole-brain radiotherapy in addition to radiosurgery?

机译：除了放射外科手术之外，患有乳腺癌的极少有脑转移的患者还能从全脑放射治疗中受益吗？

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Background An important issue in palliative radiation oncology is the whether whole-brain radiotherapy should be added to radiosurgery when treating a limited number of brain metastases. To optimize personalized treatment of cancer patients with brain metastases, the value of whole-brain radiotherapy should be described separately for each tumor entity. This study investigated the role of whole-brain radiotherapy added to radiosurgery in breast cancer patients. Methods Fifty-eight patients with 1–3 brain metastases from breast cancer were included in this retrospective study. Of these patients, 30 were treated with radiosurgery alone and 28 with radiosurgery plus whole-brain radiotherapy. Both groups were compared for local control of the irradiated metastases, freedom from new brain metastases and survival. Furthermore, eight additional factors were analyzed including dose of radiosurgery, age at radiotherapy, Eastern Cooperative Oncology Group (ECOG) performance score, number of brain metastases, maximum diameter of all brain metastases, site of brain metastases, extra-cranial metastases and the time from breast cancer diagnosis to radiotherapy. Results The treatment regimen had no significant impact on local control in the univariate analysis (p?=?0.59). Age ≤59 years showed a trend towards improved local control on univariate (p?=?0.066) and multivariate analysis (p?=?0.07). On univariate analysis, radiosurgery plus whole-brain radiotherapy (p?=?0.040) and ECOG 0–1 (p?=?0.012) showed positive associations with freedom from new brain metastases. Both treatment regimen (p?=?0.039) and performance status (p?=?0.028) maintained significance on multivariate analysis. ECOG 0–1 was positively correlated with survival on univariate analysis (p?
机译：背景姑息放疗肿瘤学中的一个重要问题是，在治疗数量有限的脑转移瘤时，是否应在放射外科手术中增加全脑放疗。为优化患有脑转移瘤的癌症患者的个性化治疗，应针对每个肿瘤实体分别描述全脑放射治疗的价值。这项研究调查了全脑放疗对乳腺癌患者放射外科的作用。方法这项回顾性研究纳入了58例患有乳腺癌的1–3次脑转移的患者。在这些患者中，有30例接受了单独的放射外科手术治疗，而28例接受了放射外科手术加上全脑放射治疗。两组均进行了辐射转移的局部控制，无新脑转移和生存的比较。此外，还分析了八个其他因素，包括放射外科手术的剂量，放疗的年龄，东部合作肿瘤小组（ECOG）的性能评分，脑转移的数目，所有脑转移的最大直径，脑转移的部位，颅外转移和时间从乳腺癌的诊断到放射治疗。结果在单因素分析中，治疗方案对局部控制无显着影响（p≤0.59）。 ≤59岁的年龄在单变量（p？=？0.066）和多变量分析（p？=？0.07）上显示出改善局部控制的趋势。单因素分析显示，放射外科手术加全脑放射治疗（p？=？0.040）和ECOG 0-1（p？=？0.012）显示与新发脑转移的自由度呈正相关。在多变量分析中，治疗方案（p≤0.039）和治疗状态（p≤0.028）均保持显着性。单因素分析表明，ECOG 0-1与生存率呈正相关（p <0.001）。 ≤59岁的年龄呈强趋势（p？=？0.054）。在多变量分析中，表现状态（p <0.001）和年龄（p = 0.041）很显着。结论在仅有少量脑转移的乳腺癌患者中，放射外科加全脑放射治疗比单独的放射外科显着改善了新发脑转移的自由度。但是，这种优势并未导致明显更好的生存。

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