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首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >A Score to Identify Patients with Brain Metastases from Colorectal Cancer Who May Benefit from Whole-brain Radiotherapy in Addition to Stereotactic Radiosurgery/Radiotherapy
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A Score to Identify Patients with Brain Metastases from Colorectal Cancer Who May Benefit from Whole-brain Radiotherapy in Addition to Stereotactic Radiosurgery/Radiotherapy

机译：除了立体定向放射外科/放射疗法外，可以从全脑放射治疗中受益的结直肠癌患者患有脑转移患者的分数

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摘要

Aim: To design a tool to predict the probability of new cerebral lesions after stereotactic radiosurgery/radiotherapy for patients with 1-3 brain metastases from colorectal cancer. Patients and Methods: In 21 patients, nine factors were evaluated for freedom from new brain metastases, namely age, gender, Karnofsky performance score (KPS), tumor type, number, maximum total diameter of all lesions and sites of cerebral lesions, extra-cranial metastases, and time from cancer diagnosis to irradiation. Results: Freedom from new lesions was positively associated with KPS of 90-100 (p=0.013); maximum total diameter = 15 mm showed a trend for positive association (p=0.09). Points were assigned as: KPS 70-80=1 point, KPS 90-100=2 points, maximum diameter = 15 mm=2 points and maximum diameter 15 mm=1 point. Six-month rates of freedom from new lesions were 29%, 45% and 100% for those with total scores of 2, 3 and 4 points, respectively, with corresponding 12-month rates of 0%, 45% and 100% (p=0.027). Conclusion: This study identified three risk groups regarding new brain metastases after stereotactic irradiation. Patients with 2 points could benefit from additional whole-brain radiotherapy.
机译：目的：设计一种预测1-3例脑转移患者的终身放射外科/放射治疗患者的脑病变的工具。患者和方法：在21例患者中，评估了九种因素，用于新脑转移的自由，即年龄，性别，卡诺夫斯基性能评分（KPS），肿瘤类型，数量，最大总直径，所有病变和脑病位的遗址，超 - 颅骨转移，以及从癌症诊断到辐照的时间。结果：新病变的自由与90-100的KPS呈正相关（P = 0.013）;最大总直径＆ 15 mm显示阳性关联的趋势（p = 0.09）。分配点为：KPS 70-80 = 1点，KPS 90-100 = 2点，最大直径= 15毫米= 2点和最大直径＆ 15 mm = 1点。六个月的新病变的自由率分别为2,3和4点的总评分的29％，45％和100％，相应的12个月率为0％，45％和100％（P = 0.027）。结论：本研究确定了三种脑转移后的三种风险群体静态照射后。 2分的患者可以从额外的全脑放射治疗中受益。

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