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首页> 外文期刊>Revista Cubana de Hematología, Inmunología y Hemoterapia >Caracterizaci?3n biol?3gica del marcador CD66c y su importancia cl?-nica en la leucemia linfoide aguda
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Caracterizaci?3n biol?3gica del marcador CD66c y su importancia cl?-nica en la leucemia linfoide aguda

机译：CD66c标记的生物学特性及其在急性淋巴白血病中的临床意义

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摘要

Leukemias are a heterogeneous group of blood diseases with a diverse etiology, pathogenesis, natural history and prognosis in which a clonal proliferation may be triggered. Acute lymphoid leukemia (ALL) is one of the most common types of cancer in children, it is characterized by the infiltration of neoplastic cells from the haematopoietic system to the bone marrow, blood and other tissues. Until 30 years ago, it was considered fatal; nowadays, the five-year survival rate exceeds 70 % , which implies that most patients may heal. Nevertheless, in developing countries the situation might be different for pediatric population; it is estimated that cancer survival rate ranges between 10 and 20 % less than those children living in developed countries. One of the immunophenotype markers that has been relevant in the last few years in the diagnosis of B-ALL and the follow-up of the minimal residual disease is CD66c. This is a member of the glycoprotein family from the carcinoembryonic antigen with a cellular adhesion function that has been widely used as a tumor marker as discovered by Sven Berg in the late 1970's. This antigen has been identified as a superficial protein expressed on the granulocytes and it is also involved in several biological functions, including cellular adhesion, migration, signal transduction and regulation of gene expression. This antigen is frequently presented in several types of cancer and its overexpression is often associated with a poor response to treatment and a decrease of survival rates for patients. Several studies have evidenced that this marker is relatedwith the presence of several chromosomal abnormalities, such as: BCR-ABL, CRLF2, and hyperdiploidy, which may help in the disease prognosis.
机译：白血病是血液疾病的异质性组，其病因，发病机制，自然病史和预后各不相同，在这些疾病中可能触发克隆增殖。急性淋巴白血病（ALL）是儿童最常见的癌症类型之一，其特征是肿瘤细胞从造血系统浸润到骨髓，血液和其他组织。直到30年前，它才被认为是致命的。如今，五年生存率超过70％，这意味着大多数患者都可以he愈。然而，在发展中国家，儿童的情况可能有所不同。据估计，癌症存活率比发达国家的儿童低10％至20％。在最近几年中，与B-ALL的诊断以及最小残留病的随访相关的免疫表型标记之一是CD66c。这是具有细胞粘附功能的癌胚抗原糖蛋白家族的一个成员，被Sven Berg在1970年代后期发现，被广泛用作肿瘤标志物。该抗原已被鉴定为在粒细胞上表达的表面蛋白，并且还参与了多种生物学功能，包括细胞粘附，迁移，信号转导和基因表达的调控。该抗原经常出现在几种类型的癌症中，其过表达通常与对治疗的不良反应以及患者生存率降低相关。多项研究表明，该标志物与多种染色体异常有关，例如：BCR-ABL，CRLF2和超二倍体，可能有助于疾病的预后。

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