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首页> 外文期刊>Revista Brasileira de Fruticultura >Chemical composition, anti-Trypanosoma cruzi and cytotoxic activities of the essential oil from green fruits of Protium ovatum (BURSERACEAE)
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Chemical composition, anti-Trypanosoma cruzi and cytotoxic activities of the essential oil from green fruits of Protium ovatum (BURSERACEAE)

机译：卵形Pro绿色水果（BURSERACEAE）的香精油的化学成分，抗台氏锥虫和细胞毒活性

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ESTEVAM, Elisangela Barbosa Borges et al. Chemical composition, anti-Trypanosoma cruzi and cytotoxic activities of the essential oil from green fruits of Protium ovatum (BURSERACEAE). Rev. Bras. Frutic. [online]. 2018, vol.40, n.1, e-794. ?Epub?Mar?08, 2018. ISSN 0100-2945.? http://dx.doi.org/10.1590/0100-29452018794. Chagas disease is a major neglected tropical disease caused by Trypanosoma cruzi. It has been treated with the antiparasitic drugs nifurtimox and benzonidazole, which cause several side effects. The market for natural products has considerably grown lately and the use of plants has become an alternative to the development of novel drugs to cure the disease. Therefore, this study aimed at describing the chemical analysis of the essential oil from green fruits of Protium ovatum and evaluating their trypanocidal and cytotoxic potential. The essential oil was obtained by Clevenger hydrodistillation whereas its chemical composition was determined by gas chromatography coupled to mass spectrometry (GC-MS). The major compounds found in the essential oil from green fruits of P. ovatum were ?-myrcene (62.0 %), a-pinene (11.3 %) and limonene (7.3 %). To the best of our knowledge, this was the first time that the chemical composition of the essential oil from green fruits of P. ovatum was described. Results showed that the essential oil had strong trypanocidal activity against trypomastigote forms of theY strain of Trypanosoma cruzi (IC50 = 1.2 μg/mL). In addition, the essential oil from green fruits of P. ovatum did not display cytotoxicity against LLCMK2 adherent epithelial cell at the concentration range under analysis (CC50 = 550.3 μg/mL). As a result, it is an excellent option for the development of novel antiparasitic drugs.
机译：ESTEVAM，Elisangela Barbosa Borges等。卵形Pro绿色水果（BURSERACEAE）的香精油的化学成分，抗台氏锥虫和细胞毒活性。胸罩牧师果然[线上]。 2018，vol.40，n.1，e-794。 Epub，2018年3月8日。ISSN0100-2945。 http://dx.doi.org/10.1590/0100-29452018794。恰加斯病是由克鲁斯锥虫引起的一种主要的被忽视的热带病。它已经用抗寄生虫药硝呋替莫和苯并硝唑治疗，它们会引起多种副作用。天然产物的市场近来发展迅速，使用植物已成为开发可治愈该疾病的新药的替代方法。因此，本研究旨在描述来自卵形t绿色水果的香精油的化学分析，并评估其锥虫和细胞毒性的潜力。通过Clevenger加氢蒸馏获得精油，而其化学组成通过气相色谱-质谱联用（GC-MS）确定。在来自卵巢假单胞菌绿色果实的精油中发现的主要化合物为α-月桂烯（62.0％），α-pine烯（11.3％）和li烯（7.3％）。据我们所知，这是第一次描述了来自P. ovatum绿色果实的香精油的化学成分。结果表明，该精油对克氏锥虫Y株的锥虫病具有很强的杀锥虫活性（IC50 = 1.2μg/ mL）。此外，在所分析的浓度范围内（CC50 = 550.3μg/ mL），来自卵形假单胞菌绿色果实的精油对LLCMK2粘附的上皮细胞没有细胞毒性。因此，它是开发新型抗寄生虫药物的绝佳选择。

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