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Human Papillomavirus: Confronting the Epidemic—A Urologist’s Perspective

机译:人乳头瘤病毒:面对流行病-泌尿科医师的观点

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The human papillomavirus (HPV) has long been associated with the development of penile lesions—condyloma acuminatum and verrucous carcinoma of the penis. More recently, HPV has been implicated as an etiology of more serious neoplasias in men—penile carcinoma and other anogenital squamous-cell carcinomas. HPV is now widely recognized as responsible for more than 95% of cervical cancers in women. HPV seems to have been receiving relatively scant attention to date—from physicians in general, and particularly from urologists—as a venereal disease of significant concern. Yet HPV is recognized to be the most frequently acquired sexually transmitted viral infection worldwide. It is estimated that approximately 6 million new cases of HPV are sexually transmitted annually in the United States. Fortunately, many, if not most, of these HPV infections are transient. However, each newly acquired infection has the potential to persist as an incurable, lifelong affliction, generating a significant increase in the long-term risk of cancer for patients and their sexual partners. Many of these HPV-related cancers will not become manifest until decades later.
机译:人类乳头瘤病毒(HPV)长期以来一直与阴茎病变-尖锐湿疣和阴茎疣状癌的发展有关。最近,HPV被认为是男性更严重的瘤形成的病因-阴茎癌和其他肛门生殖器鳞状细胞癌。现在,HPV被公认为导致95%以上的女性子宫颈癌的原因。迄今为止,HPV作为一种受到严重关注的性病,受到了一般医生(尤其是泌尿科医师)的关注相对较少。然而,HPV被公认为是全球范围内最常获得的性传播病毒感染。据估计,在美国,每年约有600万新的HPV性传播病例。幸运的是,许多(即使不是大多数)HPV感染是暂时性的。但是,每种新获得的感染都有可能作为无法治愈的终生折磨而持续存在,从而使患者及其性伴侣的长期癌症风险大大增加。许多与HPV相关的癌症要到几十年后才会显现出来。

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