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首页> 外文期刊>Revista Brasileira de Farmacognosia >Glycolipids from macroalgae: potential biomolecules for marine biotechnology?
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Glycolipids from macroalgae: potential biomolecules for marine biotechnology?

机译：大型藻类中的糖脂：海洋生物技术的潜在生物分子？

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Brown, red and green algae from the Southeastern coast of Brazil were successively extracted with chloroform/methanol 2:1 and 1:2 (v/v). The crude lipid extract was partitioned according to Folch and the lower phase enriched in glycolipids was fractionated on a silica gel column chromatography eluted with chloroform, acetone and methanol. Three major orcinol-reactive bands present in the acetone and methanol fractions were detected by thin-layer chromatography with chromatographic mobilities corresponding to sulfoglycolipids and glycosyldiacylglycerols. These fractions exhibited potent antiviral activity against HSV-1-ACVs and HSV-1-ACVr and present low toxicity for cell cultures. Purification and identification of these bioactive glycolipids will be necessary in order to elucidate their primary structures and mechanism of action.
机译：巴西东南海岸的棕色，红色和绿色藻类依次用氯仿/甲醇2：1和1：2（v / v）提取。根据Folch分配粗制脂质提取物，并将富含糖脂的下层相在硅胶柱色谱上分离，用氯仿，丙酮和甲醇洗脱。通过薄层色谱法检测到丙酮和甲醇馏分中存在的三个主要的对角酚反应带，其色谱迁移率分别对应于磺基糖脂和糖基二酰基甘油。这些级分显示出针对HSV-1-ACV和HSV-1-ACVr的有效抗病毒活性，并且对细胞培养的毒性较低。为了阐明其主要结构和作用机理，有必要纯化和鉴定这些生物活性糖脂。

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