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首页> 外文期刊>Revista Cubana de Estomatología >Density of mast cells in lesions of actinic cheilitis
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Density of mast cells in lesions of actinic cheilitis

机译：光化性唇炎的肥大细胞密度

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Objective: analyze the density of mast cells in Actinic cheilitis according to the histological characteristics of the lesion compared with the normal mucosa. Methods: descriptive study where the sample consisted of two groups, the first with 33 specimens of cases of actinic cheilitis diagnosed clinically, and the second consists of 9 specimens of normal oral mucosa, registered in the Service of Head and Neck Hospital Dr. Napoleon Laureano, João Pessoa, PB. The paraffin blocks of the sample were cut and stained with hematoxylin and eosin to assess the degree of dysplasia and inflammatory infiltrate, and toluidine blue to quantify mast cells. The count of mast cells was performed with the aid of a square grid in the case of field 8. The final reading was expressed with an average value of mast cells by case / μm². Data were analyzed by SPSS (Statistical Package for Social Sciences) version 15.0. Results: in 57.6 % of cases there was some degree of dysplasia, and 39.4 % mild, 15.2 % moderate and 3 % severe. 21.2 % had squamous cell carcinoma. The presence of inflammatory infiltrate and solar elastosis was observed in 84.9 % and 81.8 %, respectively. Mast cells were identified in 87.8 % of the sample. The density of mast cells in cases of Actinic Cheilitis was 17.4 ± 10.4 cells / μm² and 1.78 ± 1.64 normal tissue cells / μm² (p 0.001). There was a statistically significant correlation between mast cell density with the processes of dysplasia (p = 0.004) and inflammatory cell infiltration (p = 0.000). Conclusion: the increase in mast cell density in actinic cheilitis lesions and its correlation with the processes of inflammation and dysplasia suggest involvement of these cells in disease progression for Squamous Cell Carcinoma lip.
机译：目的：根据与正常黏膜相比的病变组织学特征，分析光化性唇炎中肥大细胞的密度。方法：描述性研究，其中样本包括两组，第一组包括临床诊断出的光化性唇炎病例的33个标本，第二组包括9个正常口腔粘膜标本，并在头颈医院服务的Napoleon Laureano博士进行了注册，JoãoPessoa，PB。切下样品的石蜡块，用苏木精和曙红染色以评估发育异常和炎性浸润的程度，并用甲苯胺蓝定量肥大细胞。在场8的情况下，借助于正方形网格进行肥大细胞的计数。最终读数以肥大细胞的平均值表示，以格/μm2为单位。数据通过SPSS（社会科学统计软件包）15.0版进行分析。结果：在57.6％的病例中存在一定程度的发育异常，轻度为39.4％，中度为15.2％，重度为3％。 21.2％患有鳞状细胞癌。分别观察到炎性浸润和日光弹性的发生率为84.9％和81.8％。在87.8％的样品中鉴定出肥大细胞。光化性唇炎的肥大细胞密度为17.4±10.4细胞/μm²和1.78±1.64正常组织细胞/μm²（p <0.001）。肥大细胞密度与不典型增生（p = 0.004）和炎性细胞浸润（p = 0.000）之间存在统计学上的显着相关性。结论：光化性唇炎病变中肥大细胞密度的增加及其与炎症和不典型增生的相关性表明，这些细胞参与了鳞状细胞癌嘴唇的疾病进展。

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