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首页> 外文期刊>Romanian Journal of Laboratory Medicine >Evaluation of Transcription Factor 7 like 2 polymorphisms and haplotypes in risk of Type 2 Diabetes
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Evaluation of Transcription Factor 7 like 2 polymorphisms and haplotypes in risk of Type 2 Diabetes

机译：转录因子7样2多态性和单倍型在2型糖尿病风险中的评估

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Type 2 diabetes (T2D) is a chronic disorder with different genetics and environmental factors. It is one of growing diseases in the world. Previous studies show association between Transcription Factor 7 Like2 (TCF7L2) and T2D. The current study set to evaluate the relation between TCF7L2 polymorphisms and T2D in Southeast Iran. The present case-control study was done on 250 T2D and 250 healthy controls (HCs). For genotyping polymorphisms TCF7L2 (rs11196205) and (rs4132670) Amplification-Refractory Mutation System-Polymers Chain Reaction (ARMS-PCR) was used. The results showed frequency rates of GC and CC genotypes increased in patients compared to controls (31% vs. 6% and 55% vs. 8%, respectively), showing a statistically significant difference (OR=2.67(1.37-5.21), P<0.05 and OR=3.31(1.92-5.71), P< 0.05, respectively). The C allele was associated with an increased risk of T2D, with the frequency of 28% and 11% in patients and controls, respectively (OR=3.11 (2.22-4.37), P< 0.05). Another Polymorphism of this gene TCF7L2 (rs4132670) was not associated with T2D. Furthermore, the haplotype analysis revealed that rs11196205C/rs4132670C and rs11196205C/rs4132670T are risk factors against T2D (OR=2.08 (1.49-2.86, P<0.05 and OR=1.72 (1.06-2.78) P<0.05, respectively). The findings demonstrated that TCF7L2 (rs11196205) genotypes GC, CC, and allele (C) confer risk for susceptibility to T2D.
机译：2型糖尿病（T2D）是一种具有不同遗传和环境因素的慢性疾病。它是世界上越来越多的疾病之一。先前的研究表明转录因子7 Like2（TCF7L2）和T2D之间存在关联。当前的研究旨在评估伊朗东南部TCF7L2多态性与T2D之间的关系。本病例对照研究是针对250名T2D和250名健康对照（HCs）进行的。对于TCF7L2（rs11196205）和（rs4132670）基因型多态性，使用了扩增-难治性突变系统-聚合物链反应（ARMS-PCR）。结果显示，与对照组相比，患者的GC和CC基因型频率增加（分别为31％比6％和55％比8％），差异具有统计学意义（OR = 2.67（1.37-5.21），P分别为<0.05和OR = 3.31（1.92-5.71），P <0.05）。 C等位基因与T2D风险增加相关，患者和对照组的频率分别为28％和11％（OR = 3.11（2.22-4.37），P <0.05）。此基因TCF7L2（rs4132670）的另一个多态性与T2D不相关。此外，单倍型分析显示rs11196205C / rs4132670C和rs11196205C / rs4132670T是抵抗T2D的危险因素（OR = 2.08（分别为1.49-2.86，P <0.05和OR = 1.72（1.06-2.78）P <0.05）。 TCF7L2（rs11196205）基因型GC，CC和等位基因（C）赋予易患T2D的风险。

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