IMMEDIATE-RELEASE SOLID DOSAGE FORM WITH β-CAROTENE. PREFORMULATION STUDIES

LACRAMIOARA POPA; MIHAELA VIOLETA GHICA

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IMMEDIATE-RELEASE SOLID DOSAGE FORM WITH β-CAROTENE. PREFORMULATION STUDIES

机译：β-胡萝卜素的立即释放固体剂型。配方研究

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The objective of this study was to perform preformulation assays (solubilization and stability) addressed to β-carotene, aiming for a further immediate-release solid oral dosage form. The carotenoidic pigment was solubilized in water by linear water-soluble macromolecules. There was formed solid dispersion of β-carotene with different polymers. The kinetics of β-carotene oxidation in the aqueous solutions resulted were determined in the presence and in the absence of ascorbic acid (vitamin C) as antioxidant. The influence of polymer species was established. A factorial 32 experimental design completed with graphical analysis of response surface was developed in order to determine the protective action of ascorbic acid against β-carotene degradation and to optimize the solid dispersion formulation.

机译：这项研究的目的是针对β-胡萝卜素进行预制剂化试验（增溶性和稳定性），以寻求进一步的速释固体口服剂型。类胡萝卜素颜料通过线性水溶性大分子溶解在水中。 β-胡萝卜素与不同聚合物形成固体分散体。在存在和不存在抗氧化剂抗坏血酸（维生素C）的条件下，测定了水溶液中β-胡萝卜素的氧化动力学。确定了聚合物种类的影响。为了确定抗坏血酸对β-胡萝卜素降解的保护作用并优化固体分散体配方，进行了阶乘32实验设计，并完成了响应面的图形分析。

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《Romanian Journal of Biophysics》 |2003年第4期|共10页
作者
LACRAMIOARA POPA; MIHAELA VIOLETA GHICA;
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中图分类生物物理学;
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1. In Vitro Studies are Sometimes Better than Conventional Human Pharmacokinetic In Vivo Studies in Assessing Bioequivalence of Immediate-Release Solid Oral Dosage Forms [J] . James E. Polli The AAPS Journal . 2008,第2期

机译：在评估速释固体口服剂型的生物等效性方面，体外研究有时比常规的人体药代动力学体内研究更好。
2. Thermal analysis as a screening technique in preformulation studies of picotamide solid dosage forms. [J] . Mura P, Faucci MT, Manderioli A, Drug development and industrial pharmacy . 1998,第8期

机译：热分析作为吡咯酰胺固体剂型预制剂研究中的筛选技术。
3. Thermal analysis as a screening technique in preformulation studies of picotamide solid dosage forms. [J] . Mura P, Faucci MT, Manderioli A, Drug development and industrial pharmacy . 1998,第8期

机译：热分析作为吡咯酰胺固体剂型预制剂研究中的筛选技术。
4. Preformulation Studies To Meet The Challenges In The Manufacture Of Betaine Solid Dosage Form [C] . Cletus Nunes, Jun Han, Donald C. Monkhouse, Proceedings of the 31st annual conference of the North American Thermal Analysis Society(NATAS) . 2003

机译：预配制研究以应对甜菜碱固体剂型生产中的挑战
5. Controlled release solid dispersion of metoprolol succinate for direct use in the preparation of multiple strengths solid dosage forms. [D] . Renawala, Harshil Kaushik Raksha. 2016

机译：琥珀酸美托洛尔的控释固体分散体，可直接用于制备多种强度的固体剂型。
6. In Vitro Studies are Sometimes Better than Conventional Human Pharmacokinetic In Vivo Studies in Assessing Bioequivalence of Immediate-Release Solid Oral Dosage Forms [O] . James E. Polli 2008

机译：在评估速释固体口服剂型的生物等效性方面体外研究有时比常规的人体药代动力学体内研究更好。
7. In Vitro Studies are Sometimes Better than Conventional Human Pharmacokinetic In Vivo Studies in Assessing Bioequivalence of Immediate-Release Solid Oral Dosage Forms [O] . Polli, James E. 2008

机译：在评估速释固体口服剂型的生物等效性方面，体外研究有时比常规的人体药代动力学体内研究更好。

IMMEDIATE-RELEASE SOLID DOSAGE FORM WITH β-CAROTENE. PREFORMULATION STUDIES

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