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首页> 外文期刊>Romanian Journal of Biophysics >GATING OF THE Ca2+ CHANNEL AND THE KINETICS OF ELEMENTARY CALCIUM RELEASE EVENTS
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GATING OF THE Ca2+ CHANNEL AND THE KINETICS OF ELEMENTARY CALCIUM RELEASE EVENTS

机译：Ca 2+通道的门控和基本钙释放事件的动力学

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By using a three-module decomposition of the inositol 1,4,5-trisphosphate receptor we describe both steady-state and dynamic features of the channel activity. Good agreement with published experimental data is obtained by estimating the errors introduced by missed events during single channel recordings. Inactivation as well as incremental detection at the receptor level can be well reproduced by the model in both deterministic and stochastic approaches. By simulating calcium release at individual sub cellular sites we find that the kinetics of elementary calcium events can be consistently explained by assuming that receptors are disposed as clusters with outputs located on the membrane of thin tubules of the endoplasmic reticulum, rather than assuming a spherical or hemispherical symmetry around a point source as generally accepted.
机译：通过使用肌醇1,4,5-三磷酸受体的三模块分解，我们描述了通道活性的稳态和动态特征。通过估计单通道记录期间错过事件引起的错误，可以与已发布的实验数据保持良好的一致性。该模型可以在确定性方法和随机方法中很好地再现灭活以及受体水平的增量检测。通过模拟钙在各个亚细胞部位的释放，我们发现基本钙事件的动力学可以一致地解释，方法是假定受体呈簇状排列，输出位于内质网细管膜上，而不是球形或球形。公认的点源周围的半球对称性。

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