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首页> 外文期刊>Romanian Journal of Biophysics >BIOPHYSICAL AND BIOCHEMICAL CHANGES IN THE CHARACTERISTICS OF RAT BLOOD EXPOSED TO COMBINED ALTERNATING AND STATIC MAGNETIC FIELDS
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BIOPHYSICAL AND BIOCHEMICAL CHANGES IN THE CHARACTERISTICS OF RAT BLOOD EXPOSED TO COMBINED ALTERNATING AND STATIC MAGNETIC FIELDS

机译：交变和静态磁场共同作用下大鼠血液的生物物理和生物化学变化

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摘要

The present work is devoted to study the effect of exposing experimental male albino rats to a combined static and extremely low frequency (ELF) alternating magnetic fields of average intensity 3 mT, to evaluate the risk on human workers who occupationally exposed to similar fields. A total of thirty male albino rats were equally divided into three groups, A, B, and C. Group A served as control group. Group B was exposed to static and extremely low frequency magnetic fields of 3mT, 8 hours/day for two successive weeks. Group C was exposed to the same condition as group B for four successive weeks. Osmotic fragility of RBCs, dielectric dispersion of hemoglobin (Hb) at frequency range of 12–105 Hz, Hb absorption, Hb electrophoresis, plasma alanine transaminase (ALT), aspirate transaminase (AST), malondialdehyde (MDA) levels and red blood cells (RBCs) Catalase activity were carried out for all groups. The results indicated that, exposure of animals to MFs of 3 mT, result in increase in RBCs osmotic fragility and decrease in its membrane elasticity, a partial change in Hb molecular structure without change in electrophoretic band of Hb, increase in ALT and AST levels in plasma indicating some damage in liver cell membrane. The increase in MDA level and catalase activity indicates an increase in free radicals level.
机译：本工作致力于研究将实验性雄性白化病大鼠暴露于平均强度为3 mT的静态和极低频（ELF）交流交变磁场中的作用，以评估职业性暴露于类似磁场的人类工人的风险。将总共​​三十只雄性白化病大鼠平均分为三组，即A，B和C。A组为对照组。 B组连续8周/天暴露于3mT的静态和极低频磁场中，每天8小时。 C组连续四个星期与B组处于相同状态。红细胞的渗透性脆弱性，在12–105 Hz频率范围内的血红蛋白（Hb）介电弥散，Hb吸收，Hb电泳，血浆丙氨酸转氨酶（ALT），吸出转氨酶（AST），丙二醛（MDA）水平和红细胞（ RBC）过氧化氢酶活性在所有组中均进行。结果表明，动物暴露于3 mT的MFs会导致RBCs渗透脆性增加，膜弹性降低，Hb分子结构发生部分变化，而Hb电泳带没有变化，而ALT和AST水平升高。血浆表明肝细胞膜受损。 MDA水平和过氧化氢酶活性的增加表明自由基水平的增加。

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