• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Life Science Journal >Biochemical and biophysical variations in the characteristics of rat blood exposed to magnetic fields 'in vivo study'
【24h】

Biochemical and biophysical variations in the characteristics of rat blood exposed to magnetic fields 'in vivo study'

机译：暴露于磁场中的大鼠血液特征中的生化和生物物理变化“体内研究”

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To study the effects of magnetic field (MF) of strength 50Hz-5mT on some biochemical properties of rat tissue. Forty eight of male albino rats were used, of average weight 170 ± 10gm. The animals were housed in the same environmental conditions in plastic cages, and feed with balanced diet and tap water. The animals were divided into two groups as follows: Group A: Consists of 8 animals used as a sham radiation group and housed at normal environmental conditions of pressure and temperature. The temperature inside the lab varied between 22oC and 25oC during the experimental period. Lighting condition was day light and darkness during night. Group B: Consists of 40 animal was divided into four subgroups (8 animals for each group) namely B1, B2, B3, B4 and B5, which were exposed to the magnetic field of 5 mT for a period of one week, two weeks, three weeks, and four weeks respectively. Group B5 was exposed for a period of four weeks and used for performing the required analysis after 45 days (for delayed effect study). The results indicated that there are a significant decrease in the hematological constituents of blood such as haemoglobin concentration Hb, hematocrit percentage and red blood cells count RBCs as compared to control group, but there is an improvement for the recovery group B5. The viscosity of the blood was increased for animals of all groups as compared with control group A. The differences in viscosity demonstrate the effects of RBCs aggregation and deformability respectively. The result showed that the changes in liver enzymes and total protein from blood serum analysis showed that MF produced alteration in biochemical parameters of the liver transaminases SGOT and SGPT which have been widely utilized in mammalian toxicology as biomarkers of specific organ dysfunction. In general the increase in transaminases activity is usually associated with hepatocyte damage. While the kidney functions revealed a significant increase in the concentration of urea and creatinine compared with the control group (non-exposed). The increase of the concentration of urea and creatinine causes chronic complications in some organs of the body. it will be concluded that this study suggests that, in humans under investigation, the activities of liver enzymes GOT and GPT may increase by exposure to MF generated during magnetic resonance imaging or nuclear magnetic resonance procedures.
机译：研究强度为50Hz-5mT的磁场（MF）对大鼠组织某些生化特性的影响。使用了48只雄性白化病大鼠，平均体重为170±10gm。在相同的环境条件下将动物圈养在塑料笼中，并以均衡饮食和自来水喂养。将动物分为以下两组：A组：由8只动物用作假放射组，并在正常的压力和温度环境条件下饲养。在实验期间，实验室内部的温度在22oC和25oC之间变化。光照条件是白天白昼和夜晚。 B组：将40只动物分为B1，B2，B3，B4和B5这四个亚组（每组8只动物），分别暴露于5 mT的磁场下一周，两周，三个星期和四个星期。 B5组暴露了四个星期，并在45天后用于进行所需的分析（用于延迟效应研究）。结果表明，与对照组相比，血液的血液学成分（如血红蛋白浓度Hb，血细胞比容百分比和红细胞计数）显着降低，但恢复组B5有改善。与对照组A相比，所有组动物的血液粘度均增加。粘度差异分别证明了RBC聚集和变形能力的影响。结果表明，从血清分析中发现的肝酶和总蛋白的变化表明，MF产生了肝转氨酶SGOT和SGPT的生化参数的变化，这些变化已在哺乳动物毒理学中广泛用作特定器官功能障碍的生物标志物。通常，转氨酶活性的增加通常与肝细胞损伤有关。与对照组（未暴露）相比，肾脏功能显示尿素和肌酐的浓度显着增加。尿素和肌酐浓度的增加会引起身体某些器官的慢性并发症。可以得出结论，这项研究表明，在接受调查的人类中，肝脏酶GOT和GPT的活性可能会因暴露于磁共振成像或核磁共振程序中产生的MF而增加。

著录项

  • 来源
    《Life Science Journal》 |2016年第12期|共11页
  • 作者

  • 作者单位
  • 收录信息
  • 原文格式 PDF
  • 正文语种
  • 中图分类 药学;
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号