• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Romanian Journal of Biophysics >BIOPHYSICAL AND BIOCHEMICAL CHANGES IN BLOOD OF RATS EXPOSED TO LEAD TOXICITY
【24h】

BIOPHYSICAL AND BIOCHEMICAL CHANGES IN BLOOD OF RATS EXPOSED TO LEAD TOXICITY

机译：铅中毒后大鼠血液中的生物物理和生物化学变化

获取原文
       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present work is devoted to study the lead (Pb) toxicity in experimental wister male rats exposed to 2% lead acetate in drinking water and hence evaluate the risk on human workers who environmentally and occupationally exposed to similar toxicity. A total of thirty two wister male rats were equally divided into four groups, A, B, C, and D. Group A served as control group. Group B was exposed to 2% lead acetate in drinking water for one month. Group C, and D were exposed to the same condition as Group B for two months and three months respectively. Dielectric dispersion of hemoglobin (Hb) at frequency range of 20 – 3?106 Hz, hemoglobin absorption spectra, plasma alanine transaminase (ALT), aspirate transaminase (AST), alkaline phosphatase (ALP), total protein, and Cholesterol levels were carried out for all groups. The results indicated that exposure of animals to lead results in an increase in ALT, AST, ALP, and cholesterol levels in plasma of one, two and three months respectively indicating some damage in liver cell membrane. On the other hand, plasma total protein decrease significantly in the rats treated with lead. The dielectric results indicated that the studied hemoglobin of the lead treated groups has a dielectric dispersion in the frequency range used. The increase in the electrical conductivity and relaxation time for hemoglobin as compared to control could be attributed to the increased free radicals, reactive oxygen species, and peroxide radicals which results from lead toxicity, therefore there is an increase in the surface charge density of hemoglobin macromolecule. It was concluded that oral exposure of lead causes alterations in liver functions and biophysical parameters of hemoglobin.
机译：本工作致力于研究暴露于饮用水中2％醋酸铅的实验性雄性大鼠的铅（Pb）毒性，从而评估环境和职业上遭受类似毒性的人类工人的风险。将总共​​三十二只雄性雄性大鼠平均分为四组，即A，B，C和D。A组为对照组。 B组暴露于饮用水中的2％乙酸铅中一个月。 C组和D组分别与B组接触两个月和三个月。在20 – 3？106 Hz频率范围内进行血红蛋白（Hb）的介电弥散，血红蛋白吸收光谱，血浆丙氨酸转氨酶（ALT），吸出转氨酶（AST），碱性磷酸酶（ALP），总蛋白和胆固醇水平对于所有群体。结果表明，动物接触铅会导致血浆ALT，AST，ALP和胆固醇水平分别升高1、2和3个月，这表明肝细胞膜受到了一定程度的损害。另一方面，用铅治疗的大鼠血浆总蛋白显着降低。介电结果表明，所研究的铅处理基团的血红蛋白在所使用的频率范围内具有介电色散。与对照相比，血红蛋白的电导率和弛豫时间的增加可归因于铅毒性所导致的自由基，活性氧种类和过氧化物自由基的增加，因此血红蛋白大分子的表面电荷密度增加。结论是口服铅导致肝脏功能和血红蛋白生物物理参数的改变。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号