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首页> 外文期刊>Romanian Journal of Biophysics >ENDOTHELIAL DYSFUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS
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ENDOTHELIAL DYSFUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS

机译：系统性红斑狼疮的血管内皮功能障碍

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Systemic lupus erythematosus (SLE) is associated with an increased risk of atherosclerosis; endothelial dysfunction representing the first step in its pathogenesis. The aim of this study is represented by the assessment of the endothelial dysfunction in SLE and the characterization of SLE specific factors which contribute to its appearance. The study was done on 24 subjects, divided into two groups: group A (12 patients with SLE without renal involvement) and group B (12 healthy sex and age-matched controls). Total cholesterol, triglycerides, antinuclear antibodies, anti dsDNA antibodies, C3, circulating immune complexes were determined in all patients. SLE activity was assessed using SLE Disease Activity Index (SLEDAI). Endothelial function was assessed by means of flow mediated dilation (FMD) on brachial artery, using B-mode ultrasonography. The statistically analysis was done using Pearson’s test and Student’s t-test. p < 0.05 was considered statistically significant. The group of SLE patients was formed by 12 females, with the mean age of 37.16 ± 9.69 years. The values of SLE specific tests and SLEDAI were represented by: anti dsDNA antibodies 1/682 ± 1/914, C3 68.91 ± 11.91 mg/dL, circulating immune complexes 10.03 ± 2.85 μEq/mL, total cholesterol 208.66 ± 49.63 mg/dL, triglycerides 153.41 ± 46.26 mg/dL, SLEDAI 11,66 ± 3.70. The values of FMD were 8.85 ± 2.02% (group A) and 20.33 ± 6.19% (group B), p < 0.001. The statistically analysis showed a strong inverse correlation between FMD and SLEDAI, a strong correlation between FMD and C3, respective anti dsDNA antibodies, a moderate inverse correlation between FMD and circulating immune complexes, total cholesterol, systolic and diastolic blood pressure. Endothelial dysfunction is present in SLE patients even in the absence of traditional cardiovascular risk factors, due to disease’s activity.
机译：系统性红斑狼疮（SLE）与动脉粥样硬化的风险增加有关;内皮功能障碍代表其发病的第一步。这项研究的目的是通过评估SLE中的内皮功能障碍和表征其症状的SLE特定因素来表征的。该研究针对24名受试者进行，分为两组：A组（12名无肾脏受累的SLE患者）和B组（12名健康的性别和年龄匹配的对照组）。在所有患者中测定总胆固醇，甘油三酸酯，抗核抗体，抗dsDNA抗体，C3，循环免疫复合物。使用SLE疾病活动指数（SLEDAI）评估SLE活动。使用B型超声通过肱动脉血流介导的扩张（FMD）评估内皮功能。统计分析是使用Pearson检验和St​​udent t检验进行的。 p <0.05被认为具有统计学意义。 SLE患者组由12名女性组成，平均年龄为37.16±9.69岁。 SLE特异性测试和SLEDAI的值表示为：抗dsDNA抗体1/682±1/914，C3 68.91±11.91 mg / dL，循环免疫复合物10.03±2.85μEq/ mL，总胆固醇208.66±49.63 mg / dL，甘油三酸酯153.41±46.26 mg / dL，SLEDAI 11,66±3.70。 FMD值为8.85±2.02％（A组）和20.33±6.19％（B组），p <0.001。统计分析显示，FMD和SLEDAI之间有很强的反相关性，FMD和C3之间，各自的抗dsDNA抗体之间有很强的相关性，FMD和循环免疫复合物，总胆固醇，收缩压和舒张压之间的相关性中等。由于疾病的活动，即使没有传统的心血管危险因素，SLE患者仍存在内皮功能障碍。

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