FORMATION AND CHARACTERISATION OF ANTIMICROBIAL DEXTRAN NANOFIBERS

M.M. SHAWKI; A.M. HEREBA; ABEER GHAZAL

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FORMATION AND CHARACTERISATION OF ANTIMICROBIAL DEXTRAN NANOFIBERS

机译：抗菌Dextran纳米纤维的形成与表征

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Electrospinning is a fiber spinning technique driven by a high-voltage electrostatic field. Ultra-fine dextran nanofibers (DNF) mats were fabricated by electrospinning, using water as the solvent. Antimicrobial DNF were formed by fabricating moxifloxacin antibiotic loaded on the DNF to serve as antimicrobial dextran-moxifloxacin nanofibers (DMNF) mats. Characterization of DNF and DMNF were performed. The moxifloxacin release from DMNF and its antimicrobial effectiveness were studied. The DMNF showed a wide antimicrobial effect against Escherichia coli and Staphylococcus aureus bacteria and that accompanied with sustained moxifloxacin release from the DMNF mat. The potential bio-medical application for the formed nanofibers was discussed.

机译：电纺丝是一种由高压静电场驱动的纤维纺丝技术。以水为溶剂，通过静电纺丝制备了超细葡聚糖纳米纤维（DNF）垫。抗菌DNF是通过制造DNF上负载的莫西沙星抗生素以形成抗菌葡聚糖-莫西沙星纳米纤维（DMNF）垫而形成的。进行了DNF和DMNF的表征。研究了DMNF中莫西沙星的释放及其抗菌效果。 DMNF对大肠杆菌和金黄色葡萄球菌具有广泛的抗菌作用，并伴有从DMNF垫中持续释放莫西沙星的作用。讨论了所形成的纳米纤维的潜在生物医学应用。

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《Romanian Journal of Biophysics》 |2010年第4期|共12页
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M.M. SHAWKI; A.M. HEREBA; ABEER GHAZAL;
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FORMATION AND CHARACTERISATION OF ANTIMICROBIAL DEXTRAN NANOFIBERS

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