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首页> 外文期刊>Romanian Journal of Biophysics >GINKGOLIDE B EFFECTS ON ARTIFICIAL LIPID MEMBRANES
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GINKGOLIDE B EFFECTS ON ARTIFICIAL LIPID MEMBRANES

机译：银杏内酯B对人工脂质膜的作用

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Ginkgolide B (GKB) a natural substance, belonging to the family of ginkgolides from Ginkgo biloba extracts is acknowledged as a therapeutic drug having beneficial effects in neurological disorders or as a blood platelets antiaggregant. Because of the increasing interest in the mechanisms of interaction of the substance with various structures of living systems, we have proposed ourselves to follow up its effects on the artificial lipid membranes by studying the modifications induced by increasing concentrations of GKB in the electric properties of lipid membranes formed with diphytanoyl-phosphatidylcholine (DPPC) in the absence and in the presence of cholesterol. With this view two electrophysiological techniques have been used, the Black Lipid Membrane (BLM) and the Solid Supported Membrane (SSM) methods. Our results indicate that GKB binds to the lipid bilayers and that the presence of cholesterol does not influence significantly the affinity and the cooperativity of GKB binding, but leads to a decrease in the conductance as compared to the values in its absence.
机译：银杏内酯B（GKB）是一种天然物质，属于来自银杏叶提取物的银杏内酯家族，被认为是对神经系统疾病具有有益作用的治疗药物，或作为血小板抗凝集剂。由于人们越来越关注该物质与生命系统的各种结构相互作用的机制，因此我们建议通过研究GKB浓度升高对脂质电学性质的诱导作用来跟踪其对人工脂质膜的影响。在没有胆固醇存在的情况下，由二植烷酰基磷脂酰胆碱（DPPC）形成的膜。从这个角度来看，已经使用了两种电生理技术，即黑色脂质膜（BLM）和固体支持膜（SSM）方法。我们的结果表明，GKB与脂质双层结合，并且胆固醇的存在不会显着影响GKB结合的亲和力和协同作用，但与不存在时的电导率相比，电导会降低。

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