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首页> 外文期刊>Open access Rheumatology: Research and Reviews >Repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action
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Repository corticotropin injection as adjunctive therapy in patients with rheumatoid arthritis who have failed previous therapies with at least three different modes of action

机译：储存性促肾上腺皮质激素注射液作为风湿性关节炎患者的辅助治疗，该类风湿性关节炎患者以前的治疗方法至少具有三种不同的作用方式而失败

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Objective: Many types of treatment are available for patients with rheumatoid arthritis (RA), however, some patients fail to achieve remission. This report aims to determine the safety and efficacy of using repository corticotropin injection (RCI) as an adjunctive therapy in patients with RA refractory to at least three therapeutics with different mechanisms of action. Method: In this open-label, interventional, single-group study, patients received 80 U RCI twice weekly via subcutaneous injection over 12 weeks. Changes in the Ritchie–Camp Articular Index and health assessment questionnaire scores were monitored for changes from baseline measures. Results: Eight patients were enrolled and consisted of seven females and one male with an average age of 64.6 years and disease duration of 20.9 years. Use of RCI resulted in significant improvement in swollen and tender joint counts. The disease activity score 28 and the physician and patient visual analog scale scores were significantly reduced at treatment week 12. The reduction in health assessment questionnaire scores did not reach statistical significance after RCI treatment. Once RCI therapy was discontinued, all improvements in disease activity score 28, physician and patient visual analog scale, and tender and swollen joint counts achieved during treatment were lost by the week 16 follow-up visit. Conclusion: While larger clinical trials are necessary to further confirm the efficacy of RCI in patients with refractory RA, the response of patients with refractory RA in this study suggests that RCI can be an effective add-on therapy for patients who have exhausted several classes of treatments. Furthermore, this study suggests that RCI has an alternative mode of action, compared to other available antirheumatic drugs.
机译：目的：类风湿关节炎（RA）患者可采用多种治疗方法，但有些患者无法缓解。本报告旨在确定在至少三种具有不同作用机制的难治性RA难治性RA患者中，使用贮藏激素注射（RCI）作为辅助治疗的安全性和有效性。方法：在这项开放性，干预性单组研究中，患者在12周内每周两次通过皮下注射接受80 U RCI。监测Ritchie-Camp关节指数和健康评估问卷得分的变化，以了解基线测量值的变化。结果：共纳入8例患者，其中女性7例，男性1例，平均年龄64.6岁，病程20.9年。使用RCI可显着改善关节肿胀和触痛。在治疗第12周时，疾病活动评分28和医师及患者的视觉模拟量表评分均显着降低。RCI治疗后健康评估问卷评分的降低未达到统计学意义。一旦停止RCI治疗，在第16周的随访中，疾病活动评分28，医师和患者的视觉模拟量表以及在治疗过程中获得的触痛和肿胀关节计数的所有改善都将消失。结论：虽然有必要进行更大的临床试验以进一步证实RCI在难治性RA患者中的疗效，但该研究中的难治性RA患者的反应表明，RCI可以作为疲惫不堪的几类哮喘患者的有效补充疗法。治疗。此外，这项研究表明，与其他现有的抗风湿药相比，RCI具有另一种作用方式。

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