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首页> 外文期刊>Open Forum Infectious Diseases >History of Depression and Increased Risk of Sternal Wound Infection After Cardiothoracic Surgery: A Novel and Potentially Modifiable Risk Factor
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History of Depression and Increased Risk of Sternal Wound Infection After Cardiothoracic Surgery: A Novel and Potentially Modifiable Risk Factor

机译：心胸外科手术后抑郁和胸骨伤口感染风险增加的历史：一种新型且可能可改变的危险因素

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BackgroundSternal wound infection (SWI) is a leading cause of postoperative disease and death; the risk factors for SWI remain incompletely understood. The goal of the current study was to investigate the relationship between a preoperative history of depression and the risk of SWI after cardiothoracic surgery.MethodsAmong patients undergoing cardiothoracic surgery in a major academic medical center between 2007 and 2012, those in whom SWI developed (n = 129) were matched, by date of surgery, with those in whom it did not (n = 258). Multivariable logistic regression was used to examine the strength of relationships between risk factors and development of infection. History of depression was defined as a composite variable to increase the sensitivity of detection.ResultsHistory of depression as defined by our composite variable was associated with increased risk of SWI (adjusted odds ratio, 2.4; 95% confidence interval, 1.2–4.7; P = .01). Staphylococcus aureus was the most common organism isolated.ConclusionsHistory of depression was associated with increased risk of SWI. Future prospective studies are warranted to further investigate this relationship. Depression is highly treatable, and increased efforts to identify and treat depression preoperatively may be a critical step toward preventing infection-related disease and death.
机译：背景胸骨伤口感染（SWI）是术后疾病和死亡的主要原因。 SWI的危险因素仍未完全了解。本研究的目的是调查术前抑郁史与心胸外科手术后SWI风险之间的关系。方法2007年至2012年间在主要学术医学中心接受心胸外科手术的患者中，SWI的发展（n = 129）在手术日期之前与未接受手术的患者相匹配（n = 258）。多变量logistic回归用于检验危险因素与感染发展之间关系的强度。抑郁史被定义为增加检测灵敏度的一个综合变量。结果我们的综合变量所定义的抑郁史与SWI风险增加相关（校正比值比为2.4; 95％置信区间为1.2–4.7; P = .01）。金黄色葡萄球菌是最常见的分离菌。结论抑郁史与SWI风险增加有关。有必要进行进一步的前瞻性研究来进一步研究这种关系。抑郁症是可以高度治疗的，术前加大识别和治疗抑郁症的努力可能是预防感染相关疾病和死亡的关键步骤。

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