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首页> 外文期刊>Open Journal of Urology >Arp2/3 Complex Is Expressed in Oral Squamous Cell Carcinoma: An Immunohistochemical Study of 88 Cases
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Arp2/3 Complex Is Expressed in Oral Squamous Cell Carcinoma: An Immunohistochemical Study of 88 Cases

机译：Arp2 / 3复合物在口腔鳞状细胞癌中表达：88例免疫组织化学研究。

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Background: We investigated the immunohistochemical expression of Arp2/3 complex in 88 oral squamous cell carcinomas (OSCCs) and correlated it with the tumor type and grade. Materials and methods: This is a retrospective study of 88 cases of OSCCs (9 verrucous carcinomas, 4 carcinomas in situ, 37 well differentiated OSCCs, 32 moderately differentiated OSCCs, and 6 poorly differentiated OSCCs), stained with mouse monoclonal antibodies for Arp2 and Arp3. Staining was graded according to the extent of positivity by two observers. Results: Arp2 positivity was seen in 79 (89.77%) cases and Arp3 positivity in 78 (88.63%) cases. In positive cases, Arp2 expression was graded as (+) in 12.5%, (++) in 28.4% and (+++) in 48.86% of the cases; Arp3 was graded as (+) in 36.36%, (++) in 30.68% and (+++) in 21.59% of the cases. Conclusion: Expression of Arp2 and Arp3, indicative of the formation of the Arp2/3 complex, was seen in most OSCCs examined. Although no statistically significant correlation was found between the immunohistochemical expression of Arp2/Arp3 and tumor type or grade, the more common expression in invasive OSCCs than in non-invasive verrucous carcinomas and carcinomas in situ is indicative of its involvement in the biological behaviour of the lesions. The availability of Arp2/3 inhibitors that could be used in clinical practice warrants further study of the expression of Arp2/3 in OSCC.
机译：背景：我们调查了Arp2 / 3复合物在88例口腔鳞状细胞癌（OSCC）中的免疫组织化学表达，并将其与肿瘤类型和等级相关。材料和方法：这是一项88例OSCC的回顾性研究（9例疣状癌，4例原位癌，37例高分化OSCC，32例中分化OSCC和6例低分化OSCC），并用针对Arp2和Arp3的小鼠单克隆抗体染色。两名观察者根据阳性程度对染色进行分级。结果：Arp2阳性的79例（89.77％）和Arp3阳性的78例（88.63％）病例。在阳性病例中，Arp2表达的分级为（+）12.5％，（++）28.4％和（+++）48.86％;在这种情况下，Arp3的评分为（+）36.36％，（++）评分为30.68％，（+++）评分为21.59％。结论：在大多数检查的OSCC中都可以看到Arp2和Arp3的表达，表明Arp2 / 3复合物的形成。尽管在Arp2 / Arp3的免疫组织化学表达与肿瘤类型或等级之间未发现统计学上的显着相关性，但在侵袭性OSCC中比在非侵袭性疣状癌和原位癌中更常见的表达表明它参与了Arp2 / Arp3的生物学行为。病变。可以在临床实践中使用的Arp2 / 3抑制剂的可用性值得进一步研究OSCC中Arp2 / 3的表达。

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