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首页> 外文期刊>Open Journal of Veterinary Medicine >Stimulation of Phagocytosis and Production of Antibodies against Canine Herpesvirus Type 1 by Pidotimod (AdimodTM)
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Stimulation of Phagocytosis and Production of Antibodies against Canine Herpesvirus Type 1 by Pidotimod (AdimodTM)

机译：吡多莫德（AdimodTM）刺激吞噬作用和1型犬疱疹病毒抗体的产生

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摘要

Neutrophils are the most important circulating phagocytes. Circulating mono-cytes and precursors of tissue macrophages also have the ability to phagocytize. Pidotimod (ADIMODTM) exerts immunostimulatory and immunoregulatory effects through the stimulation and regulation of cellular immune responses by lymphocytes Canine herpesvirus (CHV) mainly affect puppies between the first and second weeks of age, causing high morbidity in the litter. To date, there is only one commercial vaccine in Europe to prevent disease. In this work, inactivated CHV cultures were inoculated in rabbits, adsorbed and not adsorbed to chitosan nanoparticles. Phagocytosis in the presence or absence of specific antibodies was measured. Response of virus neutralizing antibodies was also evaluated. AdimodTM enhanced the nonspecific and specific phagocytotic response. The association of the virus to the nanoparticles increased the phagocytic ability of blood cells; however, AdimodTM alone had a greater effect on phagocytic activity and generated a stronger immune response that corresponded to the increased phagocytosis (p TM was used.
机译：中性粒细胞是最重要的循环吞噬细胞。循环的单细胞和组织巨噬细胞的前体也具有吞噬能力。匹多莫德（ADIMODTM）通过刺激和调节淋巴细胞的细胞免疫反应发挥免疫刺激和免疫调节作用犬疱疹病毒（CHV）主要影响年龄在第一周和第二周之间的幼犬，从而导致幼仔发病率高。迄今为止，欧洲只有一种预防疾病的商业疫苗。在这项工作中，灭活的CHV培养物被接种到兔子体内，被吸附而不被壳聚糖纳米颗粒吸附。测量在存在或不存在特异性抗体的情况下的吞噬作用。还评估了病毒中和抗体的反应。 AdimodTM增强了非特异性和特异性吞噬反应。病毒与纳米颗粒的缔合增加了血细胞的吞噬能力。但是，单独使用AdimodTM对吞噬活性具有更大的影响，并产生了较强的免疫反应，这与吞噬作用增强有关（使用了p TM。

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