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首页> 外文期刊>Optica pura y aplicada >Predictive analysis of superficial fluorescence patterns in non-melanoma skin cancer during photodynamic therapy
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Predictive analysis of superficial fluorescence patterns in non-melanoma skin cancer during photodynamic therapy

机译：非黑素瘤皮肤癌光动力治疗过程中浅层荧光模式的预测分析

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Non - invasive treatment monitoring is one of the key elements to assess the photosensitizer activatio n during the photochemical process underlying Photodynamic Therapy (TFD) by its fluorescence. Furthermore the photosensitizer fluorescence can be employed to discriminate the pathological tissue from the healthy one. In this work the superficial fluorescen ce patterns in three different types of nonmelanoma skin cancer tumors and their photodynamic treatment response are analysed by a fluorescence based dosimetric model for PDT with topical MAL - PpIX . Results show differences of even more than 50% in the fluo rescence patterns as the treatment progresses depending on the malignant tissue type. They demonstrate the great relevance of the biological media as an additional dosimetric factor within the photodynamic context. These results contribute to the developm ent of a future customized therapy with the assistance of dosimetric tools to interpret the fluorescence images obtained during the treatment monitoring as well as in differential photodiagnosis.
机译：无创治疗监测是通过其荧光评估光动力疗法（TFD）背后的光化学过程中光敏剂活化的关键因素之一。此外，光敏剂荧光可用于区分病理组织与健康组织。在这项工作中，通过基于局部MAL-PpIX的PDT的荧光剂量模型，分析了三种不同类型的非黑色素瘤皮肤肿瘤中的荧光光谱模式及其光动力治疗反应。结果表明，随着恶性组织类型的发展，荧光模式的差异甚至超过50％。他们证明了生物介质在光动力环境中作为附加剂量学因素具有重大意义。这些结果有助于未来定制疗法的发展，借助剂量学工具来解释在治疗监测以及差异光诊断中获得的荧光图像。

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