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首页> 外文期刊>Open Journal of Obstetrics and Gynecology >The Effects of Plasma Homocysteine in PCOS Women: A Review
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The Effects of Plasma Homocysteine in PCOS Women: A Review

机译：血浆同型半胱氨酸在PCOS妇女中的作用：审查。

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Homocysteine is an intermediate substance formed during the breakdown of the amino acid methionine and may undergo remethylation to methionine or trans-sulfuration to cystathionine or cysteine. The metabolism occurs via two >pathways: remethylation to methionine, which requires folate and vitamin B12; and transsulfuration to cystathionine, which requires pyridox>al-5’-phosphate. The disturbances in the metabolic pathways lead to the accumulation of Hcy, either by insufficient transsulfuration (through CBS mutations or vitamin B6 deficiency) or by a blockage of remethylation. In the latter case, folate or vitamin B12 deficiency may be involved, as well as MTHFR. High levels> >of Hcy induce sustained injury of arterial endothelial cells, proliferation of arterial smooth muscle cells and enhance activity of key participants in vascular inflammation, atherogenesis, and vulnerability of the established atherosclerotic plaque. Hyperhomocysteinemia has become the topic of interest in recent years. It has been highly associated with increased risk for cardiovascular disorders, such as, atherosclerosis, thromboembolism and dyslipidemia. Women with PCOS show constellation of metabolic syndromes. Obesity, hyperandrogenemia and type 2 diabetes mellitus is the hallmark of PCOS which later becomes the risk factors for cardiovascular disease. Various studies had revealed the presence of increased Hcy level in PCOS women which may or may not be associated with other biochemical parameters. Intense treatment for PCOS can influence homocysteine levels.
机译：同型半胱氨酸是氨基酸甲硫氨酸分解过程中形成的中间物质，可能会发生再甲基化为甲硫氨酸或反式硫磺化为胱硫醚或半胱氨酸。代谢通过两种途径发生：重新甲基化为蛋氨酸，需要叶酸和维生素B12;并硫磺化成胱硫醚，需要吡ido醇 > al-5′-磷酸。代谢途径的紊乱会导致Hcy的积累，这可能是由于转硫不足（由于CBS突变或维生素B6缺乏）或阻止了再甲基化所致。在后一种情况下，可能涉及叶酸或维生素B12缺乏症以及MTHFR。高水平的Hcy会引起动脉内皮细胞持续损伤，动脉平滑肌细胞增殖并增强关键参与者在血管炎症，动脉粥样硬化以及已建立的动脉粥样硬化中的活性牌匾。高同型半胱氨酸血症已成为近年来关注的话题。它与心血管疾病，例如动脉粥样硬化，血栓栓塞和血脂异常的风险增加高度相关。患有PCOS的女性表现出新陈代谢综合症的星座。肥胖，高雄激素血症和2型糖尿病是PCOS的标志，后来成为心血管疾病的危险因素。各种研究表明，PCOS妇女体内Hcy水平升高，这可能与其他生化参数有关或无关。强烈治疗PCOS可影响同型半胱氨酸水平。

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