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首页> 外文期刊>Open Journal of Respiratory Diseases >Vitamin A, Vitamin E, Lutein and β-Carotene in Lung Tissues from Subjects with Chronic Obstructive Pulmonary Disease and Emphysema
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Vitamin A, Vitamin E, Lutein and β-Carotene in Lung Tissues from Subjects with Chronic Obstructive Pulmonary Disease and Emphysema

机译：慢性阻塞性肺疾病和肺气肿患者肺组织中的维生素A，维生素E，叶黄素和β-胡萝卜素

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Vitamin A (VA) and its active metabolites play an essential role in lung airway function. Patients with moderate to severe chronic obstructive pulmonary disease (COPD) have a lower serum retinol concentration, and improvement of their 1-second Forced Expiratory Volume (FEV1) is achieved with VA supplementation. In order to test our hypothesis that the VA signaling pathway is compromised in COPD, we obtained 20 lung samples from COPD patients differing in the degree of emphysema as judged by their FEV% values. All were smokers or were exposed to secondhand smoke. Levels of VA (retinol/retinyl ester), tocopherols and carotenoids (lutein, beta-carotene) in these samples were determined using HPLC. Additional analytes beside VA were included for their known roles as antioxidants and modulators of VA-action. VA levels (retinol/retinyl ester) decreased significantly with the increase in severity of emphysema. Among other analytes, α-tocopherol levels fell by 25.8% in the severe emphysema group in comparison to the mild emphysema group, and lutein levels similarly decreased in severe compared to moderate emphysema groups. However, beta-carotene levels remained unchanged. Thus there is a significant linear correlation between lung VA-levels and the severity of emphysema. There was also a significant reduction in the levels of α-, δ-tocopherol and lutein in the severe emphysema group of COPD patients who either smoked or were exposed to smoke.
机译：维生素A（VA）及其活性代谢产物在肺气道功能中起着至关重要的作用。中度至重度慢性阻塞性肺疾病（COPD）患者的血清视黄醇浓度较低，补充VA可改善其1秒强迫呼气量（FEV1）。为了检验我们的假设，即COPD中VA信号通路受到损害，我们从COPD患者中获得了20份肺气肿样本，其肺气肿程度由FEV ％值判断。所有都是吸烟者或接触过二手烟。使用HPLC测定这些样品中的VA（视黄醇/视黄酯），生育酚和类胡萝卜素（叶黄素，β-胡萝卜素）水平。 VA之外的其他分析物因其作为VA作用的抗氧化剂和调节剂的已知作用而被包括在内。 VA水平（视黄醇/视黄酯）随着肺气肿严重程度的增加而显着降低。在其他分析物中，重度肺气肿组与轻度肺气肿组相比，α-生育酚水平下降了25.8％，而重度肺气肿与中度肺气肿组相比，叶黄素水平也下降了。但是，β-胡萝卜素水平保持不变。因此，肺VA水平与肺气肿的严重程度之间存在显着的线性相关性。在吸烟或接触烟的COPD严重肺气肿组中，α-，δ-生育酚和叶黄素的水平也显着降低。

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