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首页> 外文期刊>Open Journal of Respiratory Diseases >Leg Atherosclerosis in Japanese COPD Patients: Prevalence of Undiagnosed Peripheral Artery Disease and Association between Leg Atherosclerosis and Clinical Indices
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Leg Atherosclerosis in Japanese COPD Patients: Prevalence of Undiagnosed Peripheral Artery Disease and Association between Leg Atherosclerosis and Clinical Indices

机译：日本COPD患者的腿部动脉粥样硬化：未确诊的外周动脉疾病的患病率以及腿部动脉粥样硬化与临床指标之间的关联

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Introduction: Several studies have suggested that decreased FEV1 is associated with cardiovascular risk in COPD patients. Objective: To identify the prevalence of undiagnosed peripheral artery disease (PAD) and the relationship between leg atherosclerosis and clinical indices, which predict COPD mortality in Japanese COPD patients. Methods: We performed a cross-sectional study in 51 COPD patients and 51 age-matched, healthy control smokers. We measured ankle-brachial index (ABI) as a marker of atherosclerosis of the legs, pulmonary function, body mass index, modified Medical Research Council (MMRC) dyspnea scale, and smoking pack-years. We also calculated the ADO index (Age, Dyspnea, and Obstruction), an established predictor of mortality in COPD patients. Co-morbidities including diabetes mellitus, hypertension, and hypercholesterolemia were identified from blood laboratory tests and medical records. Results: Five subjects (9.8%) had an ABI 0.9. ABI was significantly lower in the COPD patients than in the healthy control smokers (p 0.05). The prevalence of PAD was marginally higher in COPD patients than in control smokers (p = 0.09), with the prevalence of ABI 1.0 being significantly higher in COPD patients than in control smokers (p = 0.04). In the COPD patients, ABI showed significant correlations with age (p = 0.006), FEV1 (p = 0.004), smoking pack-years (p = 0.047), MMRC dyspnea scale (p = 0.0005), SaO2 (p = 0.001), andADOindex (p 0.001). Multiple linear regression modeling showed the factors associated independently with ABI were age, FEV1, smoking pack-years, MMRC dyspnea scale, and SaO2. Conclusion: The risk of leg atherosclerosis in Japanese COPD patients is higher than in smokers without COPD. Leg atherosclerosis in COPD patients is associated with clinical indices that predict COPD mortality.
机译：简介：多项研究表明，FEV1降低与COPD患者的心血管风险有关。目的：确定未诊断的外周动脉疾病（PAD）的患病率以及腿部动脉粥样硬化与临床指标之间的关系，以预测日本COPD患者的COPD死亡率。方法：我们对51名COPD患者和51名年龄匹配的健康对照吸烟者进行了横断面研究。我们测量了踝肱指数（ABI），作为腿部动脉粥样硬化，肺功能，体重指数，改良的医学研究委员会（MMRC）呼吸困难量表和吸烟年龄的标志。我们还计算了ADO指数（年龄，呼吸困难和阻塞），这是COPD患者死亡率的确定指标。从血液实验室检查和医疗记录中可以识别出合并症，包括糖尿病，高血压和高胆固醇血症。结果：五名受试者（9.8％）的ABI为0.9。 COPD患者的ABI显着低于健康对照吸烟者（p 0.05）。 COPD患者的PAD患病率略高于对照组吸烟者（p = 0.09），而COPD患者的ABI 1.0患病率明显高于对照组吸烟者（p = 0.04）。在COPD患者中，ABI与年龄（p = 0.006），FEV1（p = 0.004），吸烟年数（p = 0.047），MMRC呼吸困难量表（p = 0.0005），SaO2（p = 0.001），和ADOindex（p 0.001）。多元线性回归模型显示与ABI独立相关的因素是年龄，FEV1，吸烟年数，MMRC呼吸困难量表和SaO2。结论：日本COPD患者腿部动脉粥样硬化的危险性高于无COPD的吸烟者。 COPD患者的腿部动脉粥样硬化与可预测COPD死亡率的临床指标相关。

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