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首页> 外文期刊>Open Journal of Pathology >Multiple Spinal Intradural-Intramedullary Involvement by Metastatic Carcinoma with Neuroendocrine Differentiation with Occult Primary—An Unusual Case Report and Review of Literature
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Multiple Spinal Intradural-Intramedullary Involvement by Metastatic Carcinoma with Neuroendocrine Differentiation with Occult Primary—An Unusual Case Report and Review of Literature

机译：隐匿性原发性转移性癌伴神经内分泌分化的多发性硬脊膜内-髓内累及－罕见病例报告并文献复习

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摘要

Although vertebral column is recognized as the most common site for bony metastasis in patient with systemic malignancy, intramedullary metastases to the spinal cord is infrequent. Between 5% - 10% of cancer patients develop spinal metastasis during the course of their diseases. Intramedullary tumors are rare, comprising 3.5% of spinal metastasis. Most metastatic spinal lesions (70%) are found at the thoracic level, 20% in lumbar region and 10% in the cervical region. We report a rare biopsy proven case of intramedullary spinal metastatic carcinoma with neuroendocrine differentiation because of its unusual presentation, involving spine at multiple noncontiguous levels, which appeared as irregular small nodules on MRI. The primary tumor was most likely from occult primary in lung. Biopsy from the spinal lesion established the diagnosis of metastatic carcinoma with neuroendocrine differentiation. Therefore, in patients with spinal metastasis, a thorough work up is advised to evaluate primary site. This would help to delineate the nature and the extent of the systemic disease. We highlighted herein the clinical presentation, radiological findings particularly MRI and role of biopsy in the diagnosis and treatment of intramedullary spinal metastasis.
机译：尽管在系统性恶性肿瘤患者中，脊柱被认为是骨转移的最常见部位，但髓内转移至脊髓的情况并不常见。 5％-10％的癌症患者在疾病过程中发生脊柱转移。髓内肿瘤很少见，占脊髓转移的3.5％。多数转移性脊柱病变（70％）在胸腔被发现，在腰椎区域占20％，在颈椎区域占10％。我们报告了一个罕见的活检证实的髓内脊柱转移性癌伴神经内分泌分化的病例，因为其异常的表现，涉及多个不连续水平的脊柱，在MRI上显示为不规则的小结节。原发性肿瘤最有可能来自肺部隐匿性原发性。脊柱病变的活检确定了具有神经内分泌分化的转移性癌的诊断。因此，对于有脊柱转移的患者，建议进行彻底检查以评估原发部位。这将有助于勾勒出全身性疾病的性质和程度。我们在这里重点介绍了临床表现，放射学发现（尤其是MRI）以及活检在髓内脊柱转移瘤的诊断和治疗中的作用。

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