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首页> 外文期刊>Open Journal of Urology >Cartilage Repair by Joint Distraction and Motion Using an External Fixator for Massive Cartilage Defect
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Cartilage Repair by Joint Distraction and Motion Using an External Fixator for Massive Cartilage Defect

机译：使用外部固定器通过关节撑开和运动来修复软骨，以修复大规模软骨缺损

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摘要

The objective of the present study was to investigate our novel methods for the repair of massive cartilage defects by joint distraction and motion using an external fixator. In this study, we used a rabbit model of massive articular cartilage defect in order to evaluate the effectiveness of using joint distraction and motion with a ring-type external fixator. This external fixator has a hinged joint with a center of rotation along the femoral transepicondylar axis, which allows the knee joint to freely flex and extend. Mesenchymal cells from bone marrow, induced by spongialization, were differentiated into mature chondrocytes and formed hyaline-like cartilage as a result of joint distraction and movement. The transplantation of autologous cells expanded from bone-marrow-derived mesenchymal cells, concentrated autologous bone marrow aspirate, and concentrated autologous peripheral blood cells were all effective in promoting cartilage repair. The quality of the cartilage after long-term joint distraction for 6 months was inferior to that after 12 weeks. In general, weight bearing on the regenerated cartilage promoted cartilage repair, although this effect differed based on when gradual weight bearing was begun. Specifically, gradual weight bearing beginning at 9 weeks produced superior results to that beginning at 6 weeks. Our methods provide an optimal environment for cartilage regeneration.
机译：本研究的目的是研究使用外固定器通过关节牵引和运动来修复大软骨缺损的新方法。在这项研究中，我们使用了大关节软骨缺损的兔子模型，以评估使用环式外固定器进行关节牵引和运动的有效性。该外部固定器具有一个铰接接头，该铰链接头的旋转中心沿股跨上ep轴旋转，从而使膝关节自由弯曲和延伸。海绵化诱导的骨髓间充质细胞分化为成熟的软骨细胞，并由于关节的分散和运动而形成了透明状的软骨。自体细胞的移植从骨髓间充质细胞，浓缩的自体骨髓抽吸物和浓缩的自体外周血细胞中扩增出来，都可以有效地促进软骨修复。长期关节牵引6个月后的软骨质量不如12周后。通常，对再生软骨的负重促进了软骨修复，尽管这种效果基于逐渐开始负重的时间而有所不同。具体而言，从9周开始逐渐负重产生的效果要好于6周开始。我们的方法为软骨再生提供了最佳环境。

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