Synovial fluid hyaluronan mediates MSC attachment to cartilage, a potential novel mechanism contributing to cartilage repair in osteoarthritis using knee joint distraction

Baboolal Thomas G.; Mastbergen Simon C.; Jones Elena; Calder Stuart J.; Lafeber Floris P. J. G.; McGonagle Dennis

首页> 外文期刊>Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research >Synovial fluid hyaluronan mediates MSC attachment to cartilage, a potential novel mechanism contributing to cartilage repair in osteoarthritis using knee joint distraction

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Synovial fluid hyaluronan mediates MSC attachment to cartilage, a potential novel mechanism contributing to cartilage repair in osteoarthritis using knee joint distraction

机译：滑膜透明质酸介导MSC附着于软骨，这是一种可能的新机制，可通过膝关节牵张来修复骨关节炎中的软骨

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Objectives Knee joint distraction (KJD) is a novel, but poorly understood, treatment for osteoarthritis (OA) associated with remarkable spontaneous' cartilage repair in which resident synovial fluid (SF) multipotential mesenchymal stromal cells (MSCs) may play a role. We hypothesised that SF hyaluronic acid (HA) inhibited the initial interaction between MSCs and cartilage, a key first step to integration, and postulate that KJD environment favoured MSC/cartilage interactions.

机译：目的膝关节牵引术（KJD）是一种新颖的但知之甚少的骨关节炎（OA）治疗，与显着的自发软骨修复相关，其中滑膜液（SF）多能间充质基质细胞（MSCs）可能发挥作用。我们假设SF透明质酸（HA）抑制了MSC与软骨之间的初始相互作用，这是整合的关键第一步，并假设KJD环境有利于MSC /软骨相互作用。

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《Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research》 |2016年第5期|共8页
作者
Baboolal Thomas G.; Mastbergen Simon C.; Jones Elena; Calder Stuart J.; Lafeber Floris P. J. G.; McGonagle Dennis;
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原文格式 PDF
正文语种 eng
中图分类免疫性疾病;
关键词
Knee Osteoarthritis; Osteoarthritis; Synovial fluid; Orthopedic Surgery;

机译：膝骨关节炎;骨关节炎;积液;骨科手术;

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1. Synovial fluid hyaluronan mediates MSC attachment to cartilage, a potential novel mechanism contributing to cartilage repair in osteoarthritis using knee joint distraction [J] . Baboolal Thomas G., Mastbergen Simon C., Jones Elena, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2016,第5期

机译：滑膜透明质酸介导MSC附着于软骨，这是一种可能的新机制，可通过膝关节牵张来修复骨关节炎中的软骨
2. Whole joint MRI assessment of surgical cartilage repair of the knee: Cartilage Repair OsteoArthritis Knee Score (CROAKS) [J] . RoemerF.W., GuermaziA., TrattnigS., Osteoarthritis and cartilage . 2014,第6期

机译：膝关节外科软骨修复的全关节MRI评估：软骨修复骨关节炎膝关节评分（CROAKS）
3. Whole joint MRI assessment of surgical cartilage repair of the knee: Cartilage Repair OsteoArthritis Knee Score (CROAKS) [J] . RoemerF.W., GuermaziA., TrattnigS., Osteoarthritis and cartilage . 2014,第6期

机译：整个联合MRI评估膝关节的外科软骨修复：软骨修复骨关节炎膝关节膝关节分数（CROAKS）
4. MRI ANALYSIS OF FEMORAL CARTILAGE THICKNESS IN EARLY OSTEOARTHRITIS KNEE PATIENTS FOR UNI-CONDYLAR KNEE POTENTIAL [C] . Gokce Yildirim, Sally Arno, Ekaterina Khmelnitska, ASME summer bioengineering conference;SBC2009 . 2009

机译：单-膝电位的早期骨关节炎膝关节患者股骨软骨厚度的MRI分析
5. Analyses of minimum joint space width, bone mineral density and articular cartilage volume and thickness in and around the knee joint in healthy individuals and those with knee osteoarthritis. [D] . Beattie, Karen A. 2006

机译：分析健康个体和膝骨关节炎患者的膝关节及其周围的最小关节间隙宽度，骨矿物质密度以及关节软骨的体积和厚度。
6. Extended report: Synovial fluid hyaluronan mediates MSC attachment to cartilage a potential novel mechanism contributing to cartilage repair in osteoarthritis using knee joint distraction [O] . Thomas G Baboolal, Simon C Mastbergen, Elena Jones, -1

机译：扩展报告：滑膜透明质酸介导MSC与软骨的附着这是一种可能的新机制可通过膝关节牵张来修复骨关节炎的软骨
7. Synovial fluid hyaluronan mediates MSC attachment to cartilage, a potential novel mechanism contributing to cartilage repair in osteoarthritis using knee joint distraction [O] . Baboolal, TG, Mastbergen, SC, Jones, E, 2016

机译：滑液透明质酸介导msC与软骨的附着，这是一种利用膝关节牵引促进骨关节炎软骨修复的潜在新机制

Synovial fluid hyaluronan mediates MSC attachment to cartilage, a potential novel mechanism contributing to cartilage repair in osteoarthritis using knee joint distraction

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