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首页> 外文期刊>Open Journal of Urology >Effects of Povidone-Iodine or Ethanol Exposure on Bone Formation at the Osteotomy Site of the Proximal Tibia in Rats
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Effects of Povidone-Iodine or Ethanol Exposure on Bone Formation at the Osteotomy Site of the Proximal Tibia in Rats

机译：聚维酮碘或乙醇暴露对大鼠近端胫骨截骨部位骨形成的影响

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Background: Povidone-iodine (PVI) irrigation is currently used to decrease the frequency of postoperative surgical site infections. Ethanol (EtOH) is sometimes applied to prevent local recurrence after curettage of benign bone tumors. However, the effects of PVI and EtOH on surrounding soft tissue and on bone union are unclear. The purpose of this study was to determine whether PVI or EtOH adversely affects the cancellous bone healing of the osteotomy site at the proximal tibia in rats. Methods: A cancellous bone osteotomy was performed at the right proximal tibia in 4-month-old, female, Sprague Dawley rats. Vehicle, 10% PVI, or 95% EtOH-soaked gauze was inserted into the osteotomy site and maintained for 6 minutes. The rats were euthanized 2 or 4 weeks after the osteotomy. Results: Two weeks after treatment, the bone union rate was significantly higher in the vehicle group than in the PVI group and the EtOH group (p < 0.001). However, the bone union rate was not significantly different between the PVI and EtOH groups. There was no significant difference among the three groups in the bone union rate 4 weeks after treatment. Conclusion: PVI or EtOH delayed bone union of the cancellous bone osteotomy site of the proximal tibia in the early phase (2 weeks), but not at 4 weeks, in rats.
机译：背景：聚维酮碘（PVI）冲洗术目前用于减少术后手术部位感染的频率。有时使用乙醇（EtOH）预防刮除良性骨肿瘤后局部复发。但是，PVI和EtOH对周围软组织和骨结合的影响尚不清楚。这项研究的目的是确定PVI或EtOH是否对大鼠胫骨近端截骨部位的松质骨愈合产生不利影响。方法：在4个月大的雌性Sprague Dawley大鼠的右胫骨近端进行了松质骨截骨术。将溶媒，10％PVI或95％浸有EtOH的纱布插入截骨部位，并保持6分钟。截骨后2或4周将大鼠安乐死。结果：治疗后两周，赋形剂组的骨结合率显着高于PVI组和EtOH组（p <0.001）。但是，PVI组和EtOH组之间的骨结合率没有显着差异。治疗后4周，三组之间的骨结合率无显着差异。结论：PVI或EtOH在大鼠的早期阶段（2周）延迟了胫骨近端松质骨截骨部位的骨结合，但在4周时没有延迟。

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