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首页> 外文期刊>Orthopaedic Journal of Sports Medicine >Quantifiable Imaging Biomarkers for Evaluation of the Posterior Cruciate Ligament Using 3-T Magnetic Resonance Imaging
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Quantifiable Imaging Biomarkers for Evaluation of the Posterior Cruciate Ligament Using 3-T Magnetic Resonance Imaging

机译：使用3-T磁共振成像技术评估后交叉韧带的定量成像生物标记物

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Background: Quantitative magnetic resonance imaging (MRI) techniques, such as T2 and T2 star (T2*) mapping, have been used to evaluate ligamentous tissue in vitro and to identify significant changes in structural integrity of a healing ligament. These studies lay the foundation for a clinical study that uses quantitative mapping to evaluate ligaments in vivo, particularly the posterior cruciate ligament (PCL). To establish quantitative mapping as a clinical tool for identifying and evaluating chronic or acute PCL injuries, T2 and T2* values first must be determined for an asymptomatic population. Purpose: To quantify T2 and T2* mapping properties, including texture variables (entropy, variance, contrast, homogeneity), of the PCL in an asymptomatic population. It was hypothesized that biomarker values would be consistent throughout the ligament, as measured across 3 clinically relevant subregions (proximal, middle, and distal thirds) in the asymptomatic cohort. Study Design: Cross-sectional study; Level of evidence, 4. Methods: Unilateral knee MRI scans were acquired for 25 asymptomatic subjects with a 3.0-T MRI system using T2 and T2* mapping sequences in the sagittal plane. The PCL was manually segmented and divided into thirds (proximal, middle, and distal). Summary statistics for T2 and T2* values were calculated. Intra- and interrater reliability was assessed across 3 raters to 2 time points. Results: The asymptomatic PCL cohort had mean T2 values of 36.7, 29.2, and 29.6 ms in the distal, middle, and proximal regions, respectively. The distal PCL exhibited significantly higher mean, variance, and contrast and lower homogeneity of T2 values than the middle and proximal subregions ( P < .05). T2* results exhibited substantial positive skew and were therefore presented as median and quartile (Q) values. Median T2* values were 7.3 ms (Q1-Q3, 6.8-8.9 ms), 7.3 ms (Q1-Q3, 7.0-8.5 ms), and 7.3 ms (Q1-Q3, 6.4-8.2 ms) in the distal, middle, and proximal subregions, respectively. Conclusion: This is the first study to identify T2 and T2* mapping values, and their texture variables, for the asymptomatic PCL. The distal third of the PCL had significantly greater T2 values than the proximal or middle thirds. Clinical Relevance: T2 and T2* values of the asymptomatic PCL can provide a baseline for comparison with acute and chronic PCL injuries in future studies.
机译：背景：定量磁共振成像（MRI）技术（例如T2和T2星（T2 *）映射）已用于评估体外韧带组织并鉴定愈合韧带结构完整性的重大变化。这些研究为临床研究奠定了基础，该临床研究使用定量作图来评估体内韧带，尤其是后十字韧带（PCL）。为了将定量映射建立为识别和评估慢性或急性PCL损伤的临床工具，必须首先确定无症状人群的T2和T2 *值。目的：量化无症状人群中PCL的T2和T2 *映射属性，包括纹理变量（熵，方差，对比度，同质性）。假设在无症状队列的3个临床相关亚区域（近端，中间和远端三分之一）中测量，整个韧带的生物标志物值将保持一致。研究设计：横断面研究;证据等级：4。方法：采用3.0-T MRI系统，使用矢状面中的T2和T2 *映射序列，对25名无症状受试者进行了单侧膝部MRI扫描。手动将PCL分割成三部分（近端，中间和远端）。计算出T2和T2 *值的摘要统计量。在3个评估者到2个时间点之间评估了内部和内部的可靠性。结果：无症状PCL队列在远端，中间和近端区域的平均T2值分别为36.7、29.2和29.6 ms。与中部和近端子区域相比，远端PCL表现出明显更高的均值，方差和对比度，并且T2值的同质性更低（P <.05）。 T2 *结果显示出明显的正偏斜，因此表示为中位数和四分位数（Q）值。在远端，中部，中位T2 *值分别为7.3 ms（Q1-Q3，6.8-8.9 ms），7.3 ms（Q1-Q3，7.0-8.5 ms）和7.3 ms（Q1-Q3，6.4-8.2 ms），和近端子区域。结论：这是首次鉴定无症状PCL的T2和T2 *映射值及其纹理变量的研究。 PCL的远端三分之一的T2值明显大于近端或中间三分之一的T2值。临床相关性：无症状PCL的T2和T2 *值可为在以后的研究中与急性和慢性PCL损伤进行比较提供基准。

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