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首页> 外文期刊>Ophthalmology and therapy. >Comparison of Minimally Invasive XEN45 Gel Stent Implantation in Glaucoma Patients Without and With Prior Interventional Therapies
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Comparison of Minimally Invasive XEN45 Gel Stent Implantation in Glaucoma Patients Without and With Prior Interventional Therapies

机译：接受和未接受介入治疗的青光眼患者微创XEN45凝胶支架植入的比较

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IntroductionThe aim of our analysis was to compare the effectiveness of the XEN45 gel stent implantation in patients without and with prior glaucoma intervention. MethodsRetrospective analysis including 148 medical records of consecutive glaucoma eyes without prior glaucoma intervention (group A, n =?45) or with prior glaucoma intervention (group B, n =?103). Follow-up data up to 12?months after XEN45 gel implantation were available for all eyes. ResultsAt 12?months, qualified success (IOP reduction of ≥?20% and IOP??18?mmHg without and with medication) was achieved in 76% of eyes in group A and in 72% of eyes in group B; corresponding values for complete success (IOP reduction of ≥?20% and IOP??18?mmHg without medication) were 56% and 55%. Mean IOP was significantly reduced by 58% from 36.0?±?10.7?mmHg preoperatively to 14.2?±?3.4?mmHg at 12?months in group A ( p =?0.000) and by 53% from 31.6?±?8.9?mmHg to 14.3?±?4.2?mmHg and in group B ( p =?0.000). The mean number of hypotensive medications had significantly decreased from 3.6?±?0.8 at baseline to 0.3?±?0.7 medications in group A ( p =?0.000) and from 3.0?±?1.0 to 0.3?±?0.7 medications in group B ( p =?0.000). Needling was required in 29% of eyes in group A and in 35% of group B within 12?months. No statistically significant differences were observed between eyes without and with prior glaucoma intervention. ConclusionThe 1-year results of our retrospective analysis indicate that patients without and with previous glaucoma intervention can benefit from XEN45 gel stent implantation. Both groups achieved significant and similar reductions in IOP and hypotensive medication, with a slight trend towards greater reductions in eyes without prior glaucoma intervention. Further controlled prospective studies with longer follow-ups are required. FundingEditorial support and article processing charges were funded by Allergan.
机译：引言我们分析的目的是比较XEN45凝胶支架植入在没有青光眼干预和有青光眼干预的患者中的有效性。方法回顾性分析，包括148例无青光眼干预（A组，n =？45）或有青光眼干预（B组，n =？103）的连续青光眼的病历。 XEN45凝胶植入后长达12个月的随访数据适用于所有眼睛。结果在12个月时，A组的76％的眼睛和B组的72％的眼睛获得了合格的成功（IOP降低≥20％，IOP 18mmHg）。完全成功的相应值（不使用药物，IOP降低≥20％且IOP≤18 mmHg）分别为56％和55％。 A组的平均IOP在术前12个月时从术前的36.0？±？10.7？mmHg降低了58％（p =？0.000），从术前的31.6？±？3.4？mmHg降低了53％（p =？0.000）。 B组为14.3±±4.2？mmHg（p =？0.000）。降压药物的平均数量已从基线时的3.6？±？0.8显着下降到A组的0.3？±？0.7（p =？0.000）和B组的3.0？±？1.0到0.3？±？0.7 （p = 0.000）。在12个月内，A组的29％的眼睛和B组的35％的眼睛需要针刺。在没有和有青光眼干预的情况下，眼睛之间没有观察到统计学上的显着差异。结论我们的回顾性分析的1年结果表明，既往未接受青光眼干预的患者均可从XEN45凝胶支架植入术中受益。两组患者的眼压和降压药物均显着和相似地减少，而在没有事先青光眼干预的情况下，眼球的减少趋势略有增加。需要进一步随访的长期随访研究。资金编辑支持和文章处理费用由Allergan资助。

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