...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Oncogene >SRF is a nuclear repressor of Smad3-mediated TGF-|[beta]| signaling
【24h】

SRF is a nuclear repressor of Smad3-mediated TGF-|[beta]| signaling

机译：SRF是Smad3介导的TGF- |β|的核阻遏物。发信号

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Serum response factor (SRF) is a widely expressed transcription factor involved in immediate-early and tissue-specific gene expression, cell proliferation and differentiation. We defined a new role of SRF as a nuclear repressor of the tumor growth factor 1 (TGF-1) growth-inhibitory signal during cell proliferation. We show that SRF significantly inhibits the TGF-1/Smad-dependent transcription by associating with Smad3. SRF causes resistance to the TGF-1 cytostatic response by directly repressing the Smad transcriptional activity and Smad binding to DNA. Furthermore, we demonstrated that overexpression of SRF markedly decreases the level of Smad3 complex binding to the promoters of Smad3 target genes, p15INK4b and p21Cip1. This leads to the inhibition of expression of TGF-1-responsive genes. SRF therefore acts as a nuclear repressor of Smad3-mediated TGF-1 signaling.
机译：血清反应因子（SRF）是一种广泛表达的转录因子，参与早期及组织特异性基因表达，细胞增殖和分化。我们定义了SRF作为细胞增殖过程中肿瘤生长因子1（TGF-1）生长抑制信号的核阻遏物的新作用。我们显示，SRF通过与Smad3相关联显着抑制TGF-1 / Smad依赖性转录。 SRF通过直接抑制Smad转录活性和Smad与DNA的结合而引起对TGF-1细胞抑制反应的抗性。此外，我们证明了SRF的过表达显着降低了Smad3复合物与Smad3目标基因p15INK4b和p21Cip1的启动子结合的水平。这导致抑制TGF-1应答基因的表达。因此，SRF充当Smad3介导的TGF-1信号转导的核阻遏物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号