Human T-cell leukemia virus type I and adult T-cell leukemia

Masao Matsuoka

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Human T-cell leukemia virus type I and adult T-cell leukemia

机译：I型人T细胞白血病病毒和成人T细胞白血病

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Human T-cell leukemia virus type I (HTLV-I) causes adult T-cell leukemia (ATL) in about 5% of carriers after a long latent period. After its infection, HTLV-I promotes the clonal proliferation of HTLV-I infected cells in vivo by actions of encoded viral proteins, including Tax. However, leukemic cells frequently lack the expression of Tax by the genetic and epigenetic changes of HTLV-I provirus, suggesting that Tax is not always necessary after transformation. Alternatively, ATL cells without Tax protein could escape from the host immune system since Tax is the major target of cytotoxic lymphocytes. During the latent period, alterations of host genome accumulate, finally leading to onset of ATL.

机译：I型人T细胞白血病病毒（HTLV-1）经过长时间潜伏期后，会在约5％的携带者中引起成人T细胞白血病（ATL）。感染后，HTLV-1通过编码的病毒蛋白（包括Tax）的作用在体内促进HTLV-1感染细胞的克隆增殖。然而，由于HTLV-1原病毒的遗传和表观遗传变化，白血病细胞经常缺乏Tax的表达，这表明转化后并不总是需要Tax。另外，由于Tax是细胞毒性淋巴细胞的主要靶标，因此不含Tax蛋白的ATL细胞可以逃脱宿主免疫系统。在潜伏期，宿主基因组的改变积累，最终导致ATL的发作。

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《Oncogene》 |2003年第33期|共10页
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Masao Matsuoka;
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中图分类肿瘤学;
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1. Retraction: Inhibition of constitutively active Jak-Stat pathway suppresses cell growth of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells [J] . Mariko Tomita, Hirochika Kawakami, Jun-nosuke Uchihara, Retrovirology . 2011,第S1期

机译：缩回：抑制组成性活性Jak-Stat途径抑制人T细胞白血病病毒1型感染的T细胞系和原代成年T细胞白血病细胞的细胞生长
2. Fucoidan extracted from Cladosiphon okamuranus Tokida induces apoptosis of human T-cell leukemia virus type 1-infected T-cell lines and primary adult T-cell leukemia cells. [J] . Haneji K, Matsuda T, Tomita M, Nutrition and Cancer: An International Journal . 2005,第2期

机译：从藤本植物克拉多芬中提取的岩藻依聚糖能诱导人T细胞白血病病毒1型感染的T细胞系和原代成年T细胞白血病细胞凋亡。
3. Loss of the ex vivo but not the reinducible CD8|[plus]| T-cell response to Tax in human T-cell leukemia virus type 1-infected patients with adult T-cell leukemia|[sol]|lymphoma [J] . B Arnulf, M Thorel, Y Poirot, Leukemia . 2004,第1期

机译：体内损失，但非可诱导的CD8 | [plus] |损失成人T细胞白血病| [sol] |淋巴瘤1型人T细胞白血病病毒感染的患者对T细胞的Tax反应
4. Characterization of cancer specific human monoclonal IgM antibodies produced by hybridomas derived from a patient with adult T-cell leukemia [C] . T. KAWAHARA, A. ICHIKAWA, Y. KATAKURA, Annual Meeting of the Japanese Association for Animal Cell Technology . 2002

机译：杂交瘤产生的癌症特异性人单克隆IgM抗体的表征衍生自成人T细胞白血病患者的杂交瘤
5. Regulation of human T-cell leukemia virus type 1 infection and replication. [D] . Choudhary, Gunjan. 2010

机译：调节人类T细胞白血病病毒1型感染和复制。
6. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. [O] . M Yoshida, M Seiki, K Yamaguchi, 1984

机译：人T细胞白血病原病毒在成人T细胞白血病的所有原发肿瘤中的单克隆整合表明人T细胞白血病病毒在该疾病中具有致病作用。
7. Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. [O] . Yoshida, M, Seiki, M, Yamaguchi, K, 1984

机译：人T细胞白血病原病毒在成人T细胞白血病的所有原发肿瘤中的单克隆整合表明，人T细胞白血病病毒在该疾病中具有致病作用。
8. Leukemias Associated with Human T-Cell Lymphotropic Virus Type I in a Non-Endemic Region. (Reannouncement with New Availability Information). [R] . Ratner, L., Poiesz, B. J. 1988

机译：白血病与非地方区域的人类T细胞淋巴细胞病毒I型相关。（重新公布新的可用性信息）。

Human T-cell leukemia virus type I and adult T-cell leukemia

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