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首页> 外文期刊>Oncogene >High activin A-expression in human neuroblastoma: suppression of malignant potential and correlation with favourable clinical outcome
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High activin A-expression in human neuroblastoma: suppression of malignant potential and correlation with favourable clinical outcome

机译：人神经母细胞瘤中高激活素A的表达：抑制恶性潜能并与良好的临床结果相关

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Amplification of the MYCN oncogene contributes to the malignant progression of human neuroblastomas, but the mechanisms have remained unclear. We have previously demonstrated that N-Myc facilitates angiogenesis by downregulating an angiogenesis inhibitor identified as the inhibin A homodimer activin A. Here, we have sought to define the molecular, biological and clinical consequences of activin A expression in human neuroblastoma. We report that enhanced activin A expression suppresses proliferation and colony formation of human neuroblastoma cells with amplified MYCN in vitro; that it inhibits neuroblastoma growth and angiogenesis in vivo; that it is highly expressed in differentiated, but not undifferentiated human neuroblastomas; and that it correlates with favourable outcome of neuroblastoma patients. Our results indicate that high activin A expression plays an important beneficial role in human neuroblastoma.
机译：MYCN癌基因的扩增有助于人类神经母细胞瘤的恶性进展，但其机制仍不清楚。我们以前已经证明N-Myc通过下调被识别为抑制素A同型二聚体激活素A的血管生成抑制剂来促进血管生成。在这里，我们试图确定激活素A在人神经母细胞瘤中表达的分子，生物学和临床意义。我们报道增强的激活素A表达抑制体外扩增的MYCN的人神经母细胞瘤细胞的增殖和集落形成;在体内抑制神经母细胞瘤的生长和血管生成;在分化的但未分化的人类神经母细胞瘤中高度表达;并且与神经母细胞瘤患者的良好预后相关。我们的结果表明，高激活素A在人类神经母细胞瘤中起着重要的有益作用。

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