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Ambivalent role of BCL6 in cell survival and transformation

机译：BCL6在细胞存活和转化中的歧义作用

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The BCL6 gene is often structurally altered and probably 'misregulated' in two different types of human B-cell non-Hodgkin lymphomas (BNHL) thought to arise from germinal centre B cells. BCL6 encodes a BTB/POZ and zinc finger protein whose biochemical properties support a role as a DNA-binding transcriptional repressor and disclose, in part, the underlying mechanisms. In contrast, the study of the 'oncogenic' structural alterations of BCL6 in BNHL and of its cellular functions gives rise to much more heterogeneous data with no obvious unifying picture so that how and even whether BCL6 contributes to lymphomagenesis remains unclear. This review will summarize the current knowledge about the 'oncogenic' alterations and cellular functions of BCL6 and, based on some results, will propose the following hypotheses: (1) In various systems, including in memory T cells and also in germinal centre B cells and possibly in certain postmitotic cells, BCL6 may act by stabilizing a particular stage of differentiation. (2) Both its ambivalent effects on cell survival and the heterogeneous consequences of its alterations in BNHL suggest that BCL6 can be oncogenic not only upon overexpression or persistent expression, as often proposed, but also, similar to some of its relatives, upon 'accidental' downregulation.
机译：BCL6基因经常在结构上发生改变，并且可能在两种不同类型的人B细胞非霍奇金淋巴瘤（BNHL）中发生了结构改变，认为这是由生发中心B细胞引起的。 BCL6编码一种BTB / POZ和锌指蛋白，其生化特性支持其作为DNA结合转录阻遏物的作用，并部分揭示其潜在机制。相反，对BNHL中BCL6的“致癌”结构改变及其细胞功能的研究产生了更多的异质数据，没有明显的统一图片，因此，尚不清楚BCL6如何甚至是否有助于淋巴瘤的发生。这篇综述将总结有关BCL6的“致癌性”改变和细胞功能的当前知识，并基于一些结果，将提出以下假设：（1）在各种系统中，包括记忆T细胞以及生发中心B细胞可能在某些有丝分裂后细胞中，BCL6可能通过稳定分化的特定阶段起作用。 （2）BCL6对细胞存活的歧义影响以及BNHL改变的异质后果都表明，BCL6不仅可以像经常提出的那样，在过度表达或持续表达时具有致癌性，而且在某些“偶然”情况下也与其某些亲属相似。下调。

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