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首页> 外文期刊>Oncogene >TLR signaling by tumor and immune cells: a double-edged sword
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TLR signaling by tumor and immune cells: a double-edged sword

机译：肿瘤和免疫细胞的TLR信号传导：一把双刃剑

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The tumor cell signaling pathways that trigger the uncontrolled proliferation, resistance to apoptosis, metastasis and escape from immune surveillance are partially understood. Toll-like receptors (TLRs), which recognize a variety of pathogen-associated molecular patterns, are centrally involved in the initiation of the innate and adaptive immune responses. However, recent evidence shows that functional TLRs are also expressed on a wide variety of tumors suggesting that TLRs may play important roles in tumor biology. Activation of tumor cell TLRs not only promotes tumor cell proliferation and resistance to apoptosis, but also enhances tumor cell invasion and metastasis by regulating metalloproteinases and integrins. Moreover, the activation of TLR signaling in tumor cells induces the synthesis of proinflammatory factors and immunosuppressive molecules, which enhance the resistance of tumor cells to cytotoxic lymphocyte attack and lead to immune evasion. Thus, the neoplastic process may usurp TLR signaling pathways to advance cancer progression, which suggests that targeting tumor TLR signaling pathways may open novel therapeutic avenues.
机译：部分理解了触发不受控制的增殖，抗凋亡，转移和逃避免疫监视的肿瘤细胞信号通路。识别多种病原体相关分子模式的Toll样受体（TLR），主要参与先天和适应性免疫应答的启动。然而，最近的证据表明功能性TLRs也表达于多种肿瘤中，这表明TLRs在肿瘤生物学中可能起重要作用。肿瘤细胞TLR的激活不仅促进肿瘤细胞增殖和对凋亡的抵抗，而且通过调节金属蛋白酶和整联蛋白来增强肿瘤细胞的侵袭和转移。此外，肿瘤细胞中TLR信号的激活诱导了促炎因子和免疫抑制分子的合成，从而增强了肿瘤细胞对细胞毒性淋巴细胞攻击的抵抗力并导致了免疫逃逸。因此，肿瘤过程可能篡改TLR信号通路以促进癌症进展，这表明靶向肿瘤TLR信号通路可能会开辟新的治疗途径。

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