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首页> 外文期刊>Schizophrenia research and treatment >Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine
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Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine

机译：反复暴露于苯丙胺的幼鼠白色物质的异常行为和微观结构变化

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Amphetamine (AMP) is an addictive CNS stimulant and has been commonly abused by adolescents and young adults, during which period brain white matter is still developing. This study was to examine the effect of a nonneurotoxic AMP on the white matter of juvenile mice.d-AMP (1.0 mg/kg) was given to young male C57BL/6 mice once a day for 21 days. The spatial working memory and locomotion of mice were measured at the end. Then, mice were sacrificed and their brains were processed for morphological analyses to examine the white matter structure and for Western blot analysis to measure three main proteins expressed in mature oligodendrocytes. AMP-treated mice displayed higher locomotion and spatial working memory impairment and showed lower levels of Nogo-A and GST-pi proteins in frontal cortex and lower MBP protein in the frontal cortex and hippocampus. They also had fewer mature oligodendrocytes and weak MBP immunofluorescent staining in the same two brain regions. But the striatum was spared. These results suggest that the late-developing white matter is vulnerable to AMP treatment which is able to increase striatal and cortical dopamine. Both the compromised white matter and increased dopamine may contribute to the observed behavioral changes in AMP-treated mice.
机译：苯丙胺（AMP）是一种令人上瘾的中枢神经系统兴奋剂，通常被青少年和年轻人滥用，在此期间脑白质仍在发展。这项研究旨在检验非神经毒性AMP对幼年小鼠白质的影响。每天对雄性C57BL / 6雄性小鼠给予d-AMP（1.0μmg/ kg），持续21天。最后测量小鼠的空间工作记忆和运动能力。然后，处死小鼠，对其大脑进行形态分析以检查白质结构，并进行蛋白质印迹分析以测量成熟少突胶质细胞表达的三种主要蛋白质。 AMP处理的小鼠表现出较高的运动能力和空间工作记忆障碍，并且额叶皮层的Nogo-A和GST-pi蛋白水平较低，额叶皮层和海马的MBP蛋白水平较低。在相同的两个大脑区域中，它们的成熟少突胶质细胞也较少，MBP免疫荧光染色较弱。但是纹状体幸免了。这些结果表明，较晚发育的白质易受AMP治疗，从而能够增加纹状体和皮质多巴胺。受损的白质和增加的多巴胺都可能有助于在AMP处理的小鼠中观察到的行为变化。

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