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首页> 外文期刊>Schizophrenia research and treatment >White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia
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White Matter Abnormalities and Animal Models Examining a Putative Role of Altered White Matter in Schizophrenia

机译：白色物质异常和动物模型研究了在精神分裂症中改变的白色物质的假定作用

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Schizophrenia is a severe mental disorder affecting about 1% of the population worldwide. Although the dopamine (DA) hypothesis is still keeping a dominant position in schizophrenia research, new advances have been emerging in recent years, which suggest the implication of white matter abnormalities in schizophrenia. In this paper, we will briefly review some of recent human studies showing white matter abnormalities in schizophrenic brains and altered oligodendrocyte-(OL-) and myelin-related genes in patients with schizophrenia and will consider abnormal behaviors reported in patients with white matter diseases. Following these, we will selectively introduce some animal models examining a putative role of white matter abnormalities in schizophrenia. The emphasis will be put on the cuprizone (CPZ) model. CPZ-fed mice show demyelination and OLs loss, display schizophrenia-related behaviors, and have higher DA levels in the prefrontal cortex. These features suggest that the CPZ model is a novel animal model of schizophrenia.
机译：精神分裂症是一种严重的精神障碍，影响全世界约1％的人口。尽管多巴胺（DA）假说在精神分裂症研究中仍然占据主导地位，但近年来出现了新的进展，这表明了精神分裂症中白质异常的含义。在本文中，我们将简要回顾一些近期的人类研究，这些研究表明精神分裂症患者的精神分裂症脑白质异常以及少突胶质细胞（OL-）和髓鞘相关基因改变，并将考虑白质疾病患者报告的异常行为。在这些之后，我们将选择性地引入一些动物模型，以检查白质异常在精神分裂症中的假定作用。重点将放在cuprizone（CPZ）模型上。用CPZ喂养的小鼠表现出脱髓鞘和OLs丢失，表现出与精神分裂症相关的行为，并且在额叶前皮质中具有较高的DA水平。这些特征表明，CPZ模型是一种新型的精神分裂症动物模型。

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