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The Role of Oestrogen and Other Hormones in the Pathophysiology and Treatment of Schizophrenia

机译：雌激素和其他激素在精神分裂症的病理生理和治疗中的作用

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The theory that many serious mental illnesses, in particular psychoses such as schizophrenia, may have a significant hormonal aetiological component is fast gaining popularity and the support of scientific evidence. Oestrogen in particular has been substantially investigated as a potential mediator of brain function in schizophrenia. Epidemiological and life-cycle data point to significant differences in the incidence and course of schizophrenia between men and women suggests a protective role of oestrogen.In vitroandin vivopreclinical research confirms oestradiol’s interactions with central neurotransmitter systems implicated in the pathogenesis of schizophrenia, while results from randomised controlled trials investigating the antipsychotic potential of oestrogen have been positive. Research into other neuroactive hormones with possible effects on mental state is a rapidly evolving field that may hold new promise. Given that schizophrenia and related psychoses are pervasive and debilitating conditions for which currently available treatments are often only partially effective and entail a high risk of serious side-effects, novel therapeutic strategies are needed. The literature reviewed in this paper suggests that hormones such as oestrogen could be a viable option, and it is hoped that with further research and larger trials, the oestrogen hypothesis can be translated into effective clinical practice.
机译：许多严重的精神疾病，特别是精神分裂症等精神病，可能具有重要的激素病因学说，这一理论正在迅速普及并得到科学证据的支持。尤其是雌激素已作为精神分裂症中脑功能的潜在介体而被大量研究。流行病学和生命周期数据表明，男性和女性之间精神分裂症的发病率和病程存在显着差异，表明雌激素具有保护作用。体外和体内临床前研究证实，雌二醇与中枢神经递质系统的相互作用与精神分裂症的发病有关，而随机结果研究雌激素抗精神病药潜力的对照试验是阳性的。对可能影响精神状态的其他神经活性激素的研究是一个快速发展的领域，可能具有新的希望。鉴于精神分裂症和相关的精神病普遍存在并且使人衰弱，对于目前可用的治疗通常仅部分有效并且带来严重副作用的高风险，因此需要新的治疗策略。本文综述的文献表明，诸如雌激素之类的激素可能是一种可行的选择，并希望通过进一步的研究和更大的试验，雌激素假说可以转化为有效的临床实践。

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